Section 61
Chapter 60,150

PSEN1 gene polymorphisms in Caucasian Alzheimer's disease: a meta-analysis

Ramakrishnan, V.; Akram Husain, R.S.; Ahmed, S.S.S.J.

Clinica Chimica Acta; International Journal of Clinical Chemistry 473: 65-70


ISSN/ISBN: 1873-3492
PMID: 28821390
DOI: 10.1016/j.cca.2017.08.016
Accession: 060149537

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A meta-analysis was performed to assess PSEN1 gene polymorphisms (rs1800839 and rs17125721) in Alzheimer's disease (AD) risk. A systematic electronic search was performed across databases to retrieve studies published before 31 January 2017. The association between the selected PSEN1 polymorphisms and AD was based on five genetic models using DerSimonian and Laird's method or Mantel-Haenszel's method. A total of 14 case-controlled studies were included. Results showed that rs1800839 polymorphism was significantly associated with AD in allelic OR=0.85 (95% CI [0.72-1.00]) and dominant OR=0.82 (95% CI [0.69-0.98]) genetic models, respectively. However, an insignificant association was found for rs17125721 polymorphism in all genetic models. Meta-analysis of PSEN1 gene suggests that the rs1800839 polymorphism has potential influence on AD among Caucasians.

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