+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents

Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents

European Journal of Medicinal Chemistry 142: 459-485

In the search of novel strategies for the treatment of cancer, photodynamic therapy (PDT) has emerged as an effective, safe for repeated use, and non-invasive method. This technique involves the use of two major non-toxic components, a photosensitizer (PS) and a visible or near-infrared (NIR) light source, combined to induce cellular damage in an oxygen-dependent or -independent manner. Macrocyclic compounds, involving porphyrin and their derivatives, represent the major class of PS agents used in PDT. However, due to the drawbacks associated with these PS, like photosensitivity, dark toxicity, and low wavelength absorbance, new classes of PS appear to be needed. This review summarizes over the recent advances in drug discovery of non-porphyrinic PS suitable as anticancer therapeutics in PDT. The different compounds are grouped by chemical classes and discussed in terms of phototoxicity, together with the critical aspects of design and structure-activity relationship.

(PDF emailed within 0-6 h: $19.90)

Accession: 060175059

Download citation: RISBibTeXText

PMID: 28943196

DOI: 10.1016/j.ejmech.2017.08.070

Related references

Recent advances in drug repositioning for the discovery of new anticancer drugs. International Journal of Biological Sciences 10(7): 654-663, 2015

Anticancer multidrug resistance mediated by MRP1: recent advances in the discovery of reversal agents. Medicinal Research Reviews 25(4): 453-472, 2005

Combinatorial Approaches in Anticancer Drug Discovery: Recent Advances in Design and Synthesis. Frontiers in Medicinal Chemistry - Online 1(1): 215-235, 2004

Combinatorial approaches in anticancer drug discovery: recent advances in design and synthesis. Current Medicinal Chemistry 8(12): 1383-1404, 2001

Drug Discovery and Development of Antimalarial Agents: Recent Advances. Current Protein & Peptide Science 17(3): 275-279, 2016

Recent advances in antiviral agents: antiviral drug discovery for hepatitis viruses. Current Pharmaceutical Design 12(11): 1371-1377, 2006

Advances In the Discovery of Anthraquinone-Based Anticancer Agents. Recent Patents on Anti-Cancer Drug Discovery: -, 2017

Recent advances in the discovery and development of stilbenes and lactones in anticancer therapy. Expert Opinion on Therapeutic Patents 14(6): 819-835, 2004

Recent progress in the discovery of Akt inhibitors as anticancer agents. Expert Opinion on Therapeutic Patents 17(9): 1077-1130, 2007

Overview: Recent Advances in Antifolates as Anticancer Agents. Expert Opinion on Therapeutic Patents 2(12): 1979-1992, 1992

Recent Advances in Copper Intercalators as Anticancer Agents. Journal of Fluorescence 28(5): 1195-1205, 2018

Recent advances in the new generation taxane anticancer agents. Medicinal Chemistry ) 1(2): 125-139, 2006

Recent Advances in development of Polyphenols as Anticancer agents. Mini Reviews in Medicinal Chemistry: -, 2018

Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents. Anti-Cancer Agents in Medicinal Chemistry 15(5): 537-547, 2016

Novel anticancer agents and targets: recent advances and future perspectives. Mini Reviews in Medicinal Chemistry 13(9): 1239-1255, 2014