+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Regulation of zygotic gene activation by chromatin structure and epigenetic factors



Regulation of zygotic gene activation by chromatin structure and epigenetic factors



Journal of Reproduction and Development 63(4): 359-363



After fertilization, the genomes derived from an oocyte and spermatozoon are in a transcriptionally silent state before becoming activated at a species-specific time. In mice, the initiation of transcription occurs at the mid-one-cell stage, which represents the start of the gene expression program. A recent RNA sequencing analysis revealed that the gene expression pattern of one-cell embryos is unique and changes dramatically at the two-cell stage. However, the mechanism regulating this alteration has not yet been elucidated. It has been shown that chromatin structure and epigenetic factors change dynamically between the one- and two-cell stages. In this article, we review the characteristics of transcription, chromatin structure, and epigenetic factors in one- and two-cell mouse embryos and discuss the involvement of chromatin structure and epigenetic factors in the alteration of transcription that occurs between these stages.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 060186508

Download citation: RISBibTeXText

PMID: 28579579

DOI: 10.1262/jrd.2017-058


Related references

Involvement of chromatin structure in the regulation of mouse zygotic gene activation. Animal Science Journal 73(2): 113-122, 2002

Role of chromatin structure in zygotic gene activation in the mammalian embryo. Seminars in Cell Biology 6(4): 201-208, 1995

Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis. Current Opinion in Genetics and Development 55: 46-51, 2019

Epigenetic regulation of chromatin structure and gene function by biotin. Journal of Nutrition 136(7): 1763-1765, 2006

Epigenetic Regulation of Chromatin Structure and Gene Function by Biotin1,2. The Journal of Nutrition 136(7): 1763-1765, 2006

Epigenetic regulation of gene expression: the effect of altered chromatin structure from yeast to mammals. Human Molecular Genetics 4 Spec No: 1765-1777, 1995

Epigenetic regulation of HSP 70-1 gene transcription at onset of zygotic activity in the mouse. Journal of Cellular Biochemistry Suppl. 0(21B): 166, 1995

Regulation of zygotic gene activation in the preimplantation mouse embryo: global activation and repression of gene expression. Biology of Reproduction 64(6): 1713-1721, 2001

Epigenetic regulation of chromatin structure and gene function by biotin: are biotin requirements being met?. Nutrition Reviews 66(Suppl. 1): S46-S48, 2008

The role of transcription factors, chromatin structure and DNA replication in 5 S RNA gene regulation. Journal of Cell Science 107: 2055-2063, 1994

Structure and Epigenetic Regulation of Chromatin Fibers. Cold Spring Harbor Symposia on Quantitative Biology 82: 25-35, 2017

Regulation of zygotic gene activation in the mouse. Bioessays 15(8): 531-538, 1993

Effects of Histone Methylation Related Genes on Epigenetic Reprogramming AND ZYGOTIC GENE ACTIVATION IN OVINE SOMATIC CELL NUCLEAR TRANSFER (SCNT) EMBRYOS. Reproduction Fertility and Development 21(1): 112-112, 2009

Regulation of secondary metabolism by chromatin structure and epigenetic codes. Fungal Genetics and Biology 48(1): 62-69, 2011

Epigenetic Players of Chromatin Structure Regulation in Plasmodium falciparum. Chembiochem 20(10): 1225-1230, 2019