+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of Compounded Stanford Modified Oral Rinse (MucoLox) on the Survival and Migration of Oral Keratinocytes and Fibroblasts: Implications for Wound Healing



Effects of Compounded Stanford Modified Oral Rinse (MucoLox) on the Survival and Migration of Oral Keratinocytes and Fibroblasts: Implications for Wound Healing



International Journal of Pharmaceutical Compounding 22(1): 60-65



Several oral rinses are commercially available to alleviate the symptoms of oral mucositis. Prolonged retention of active pharmaceutical ingredients in the oral cavity is a major problem. In this study, we modified the Stanford oral rinse by including a proprietary mucoadhesive polymer called MucoLox, which we hypothesized would improve active pharmaceutical ingredient mucoadhesion. Characterization of this newly compounded oral rinse showed absence of cytotoxicity in human oral keratinocyte and fibroblast cell lines. The compounded formulation significantly stimulated the migration of these two cell lines in Oris Cell Migration Assay plates, better than the reference commercial product Magic mouthwash. Based on this in vitro study, the new Stanford modified oral rinse with MucoLox is safe and may promote healing of oral mucositis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 060219887

Download citation: RISBibTeXText

PMID: 29385386


Related references

Keratinocytes increase fibronectin deposition by fibroblasts implications in wound healing. FASEB Journal 6(4): A942, 1992

Differential effects of TGF-b1 on hyaluronan synthesis by fetal and adult skin fibroblasts: implications for cell migration and wound healing. Experimental Cell Research 228: 6-33, 1996

Proliferation, migration, and expression of oral-mucosal-healing-related genes by oral fibroblasts receiving low-level laser therapy after inflammatory cytokines challenge. Lasers in Surgery and Medicine 48(10): 1006-1014, 2016

Differential effects of TGF-beta1 on hyaluronan synthesis by fetal and adult skin fibroblasts: implications for cell migration and wound healing. Experimental Cell Research 228(2): 326-333, 1996

The use of an in vitro wound healing model, the tri-layered skin equivalent, to study the effects of cytokines on the repopulation of the wound defect by fibroblasts and keratinocytes. Biochemical Society Transactions 25(2): 369s, 1997

IL-22 mediates the oral mucosal wound healing via STAT3 in keratinocytes. Archives of Oral Biology 72: 14-20, 2016

Effects of a low-level diode laser on oral keratinocytes, oral fibroblasts, endothelial cells and osteoblasts incubated with bisphosphonates: An in vitro study. Biomedical Reports 3(1): 14-18, 2014

Oral Wound Healing Effects of Acai Berry Water Extracts in Rat Oral Mucosa. Toxicological Research 34(2): 97-102, 2018

Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice. Journal of Bone and Mineral Metabolism 28(2): 165-175, 2010

Influence of aging on fibronectin and alpha-5 integrin expression in keratinocytes and fibroblasts Implications for compromised wound healing in the elderly. Journal of Investigative Dermatology 104(4): 671, 1995

Lysophosphatidic acid induces expression of genes in human oral keratinocytes involved in wound healing. Archives of Oral Biology 80: 153-159, 2017

Recombinant tetra-cell adhesion motifs supports adhesion, migration and proliferation of keratinocytes/fibroblasts, and promotes wound healing. Experimental & Molecular Medicine 39(5): 663-672, 2007

Effects of silver nanoparticles on primary cell cultures of fibroblasts and keratinocytes in a wound-healing model. Journal of Applied Biomaterials and Functional Materials 14(2): E137-E142, 2017

Novel DNA methylation targets in oral rinse samples predict survival of patients with oral squamous cell carcinoma. Oral Oncology 50(11): 1072-1080, 2015

Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair. Periodontology 2000 68(1): 21-40, 2017