EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Signaling by Small GTPases at Cell-Cell Junctions: Protein Interactions Building Control and Networks


Signaling by Small GTPases at Cell-Cell Junctions: Protein Interactions Building Control and Networks



Cold Spring Harbor perspectives in biology 10(10)



ISSN/ISBN: 1943-0264

PMID: 28893858

DOI: 10.1101/cshperspect.a028746

A number of interesting reports highlight the intricate network of signaling proteins that coordinate formation and maintenance of cell-cell contacts. We have much yet to learn about how the in vitro binding data is translated into protein association inside the cells and whether such interaction modulates the signaling properties of the protein. What emerges from recent studies is the importance to carefully consider small GTPase activation in the context of where its activation occurs, which upstream regulators are involved in the activation/inactivation cycle and the GTPase interacting partners that determine the intracellular niche and extent of signaling. Data discussed here unravel unparalleled cooperation and coordination of functions among GTPases and their regulators in supporting strong adhesion between cells.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 060248612

Download citation: RISBibTeXText

Related references

Regulation of small GTPases at epithelial cell-cell junctions. Molecular Membrane Biology 28(7-8): 427-444, 2011

Signaling pathways in anchoring junctions of epithelial cells: cell-to-cell and cell-to-extracellular matrix interactions. Journal of Receptor and Signal Transduction Research 35(1): 67-75, 2015

Signaling networks of Rho GTPases in cell motility. Cellular Signalling 25(10): 1955-1961, 2013

Cell-Cell Junctions Organize Structural and Signaling Networks. Cold Spring Harbor Perspectives in Biology 10(4), 2018

A cross-link between protein kinase A and Rho-family GTPases signaling mediates cell-cell adhesion and actin cytoskeleton organization in epithelial cancer cells. Journal of Pharmacology and Experimental Therapeutics 327(3): 777-788, 2008

CAMs and Rho small GTPases: gatekeepers for leukocyte transendothelial migration. Focus on "VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration". American Journal of Physiology. Cell Physiology 285(2): C250-C252, 2003

Involvement of protein kinase C in the control of cell-cell and cell-matrix junctions in relation to differentiation of keratinocytes. Ohkawara, A, McGuire, J The biology of the epidermis: Molecular and functional aspects: 85-95, 1992

The Rho3 and Rho4 small GTPases interact functionally with Wsc1p, a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces cerevisiae. Microbiology 152(Part 3): 695-708, 2006

Small GTPases and control of cell proliferation. Biochemical Society Transactions 28(5): A115, 2000

HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks. Cell Cycle 5(4): 384-391, 2006

Multistage T cell-dendritic cell interactions control optimal CD4 T cell activation through the ADAP-SKAP55-signaling module. Journal of Immunology 191(5): 2372-2383, 2013

Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion. Cell Reports 29(6): 1524-1538.E6, 2019

Small Rho GTPases in the control of cell shape and mobility. Cellular and Molecular Life Sciences: Cmls 71(9): 1703-1721, 2014

Synergistic and additive interactions between receptor signaling networks drive the regulatory T cell versus T helper 17 cell fate choice. Journal of Biological Chemistry 297(6): 101330, 2021

Interactions between chromosomes, microfilaments and microtubules revealed by the study of small GTPases in a big cell, the vertebrate oocyte. Molecular and Cellular Endocrinology 282(1-2): 12-17, 2008