Solid-Phase Synthesis of β-Peptoids with Chiral Backbone Substituents Using Reductive Amination
Morimoto, J.; Fukuda, Y.; Sando, S.
Organic Letters 19(21): 5912-5915
ISSN/ISBN: 1523-7052 PMID: 29039680 DOI: 10.1021/acs.orglett.7b02909
A new submonomeric synthetic method of β-peptoids that allows introduction of chiral backbone substituents is established. The synthesis of β-peptoids with various backbone substituents on β-carbons and spectroscopic studies of synthesized oligomers are described.