+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Specific and sensitive determination of pregnancy-specific beta 1-glycoprotein by radioimmunoassay. A new pregnancy test



Specific and sensitive determination of pregnancy-specific beta 1-glycoprotein by radioimmunoassay. A new pregnancy test



Lancet 1(8007): 333-335



A specific and highly sensitive radioimmunoassay (R.I.A.) for determination of pregnancy-specific beta 1-glycoprotein (S.P.1) in human plasma, urine, amniotic fluid, and breast milk has been developed. The minimum detection limit of S.P.1 was 8 mug/1 of sample. The assay was applied to plasma and/or urine samples from 8 women in early pregnancy. S.P. 1 was detected in the plasma of all three women obtained within 14 days of ovulation, the earliest positive result being at 7 days. In another woman plasma was negative at day 18 and positive by day 22. In the three remaining women plasma S.P.1 was detected when measured within 24 to 36 days of ovulation. S.P.1 was detected in four urine samples obtained between 20 and 28 days after ovulation. S.P.1 was also measured in breast milk, amniotic fluid, cord blood, and plasma of women with ectopic gestation and trophoblastic disease. It is suggested that the assay of S.P.1 may have important advantages over existing systems for detection and monitoring of early pregnancy.

(PDF emailed within 1 workday: $29.90)

Accession: 060268515

Download citation: RISBibTeXText

PMID: 64860


Related references

The radioimmunoassay of a pregnancy specific-beta 1-glycoprotein in plasma as a pregnancy test for subfertile women. British Journal of Obstetrics and Gynaecology 87(6): 496-450, 1980

Specific and sensitive determination of pregnancy-specific beta1-glycoprotein by radioimmunoassay. Obstetrical & Gynecological Survey 32(7): 578-579, 1977

Use of a rapid radioimmunoassay for pregnancy-specific beta-1 glycoprotein in gynecologic emergencies: comparison with routine urinary pregnancy test and a rapid radioimmunoassay for human chorionic gonadotropin. American Journal of Obstetrics and Gynecology 139(8): 968-970, 1981

Radioimmunoassay in estimating the concentration of pregnancy-specific beta-1-glycoprotein (SP-1) in normal pregnancy. Polski Tygodnik Lekarski 37(7): 181-184, 1982

Identification of pregnancy from bloodstains by radioimmunoassay for pregnancy specific beta 1-glycoprotein (SP1). Nihon Hoigaku Zasshi 41(4): 279-293, 1987

Detection of pregnancy-specific beta 1-glycoprotein (SP1), of proteins of the "pregnancy zone" (PZ), of pregnancy-associated plasma protein A (PAPP-A) with 24-hour radial immunodiffusion. Detection of pregnancy-specific beta 1-glycoprotein (SP1) with turbidimetry. Current significance of the proteins. Zentralblatt für Gynakologie 105(8): 516-526, 1983

Non-specific serum/plasma response in radioimmunoassay of pregnancy-specific beta 1-glycoprotein (SP1) in healthy, non-pregnant subjects. Clinica Chimica Acta; International Journal of Clinical Chemistry 140(1): 101-108, 1984

A study on the metabolic pathway of pregnancy specific beta 1-glycoprotein (SP1). Report 1: Change of pregnancy specific beta 1-glycoprotein (SP1) in urine during normal gestation. Nihon Naibunpi Gakkai Zasshi 57(10): 1508-1520, 1981

A simple and sensitive radioimmunoassay for pregnancy-specific beta1-glycoprotein. British Journal of Obstetrics and Gynaecology 84(8): 580-584, 1977

Radioimmunoassay of "pregnancy-specific"-beta 1-glycoprotein (SP1). Clinical Chemistry 25(4): 577-580, 1979

Clinical value of pregnancy-specific beta 1-glycoprotein (SP1) and beta-hCG determination in serum in suspected ectopic pregnancy. Acta Obstetricia et Gynecologica Scandinavica 65(7): 679-683, 1986

Experiences with the pregnancy-specific beta 1-glycoprotein (SP 1) in the diagnosis of extrauterine pregnancy in comparison with HCG determination. Der Gynakologe 16(3): 173-176, 1983

Evaluation and modification of a radioimmunoassay for pregnancy-specific beta 1-glycoprotein. Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift für Klinische Chemie und Klinische Biochemie 19(12): 1197-1200, 1981

A serum pregnancy test with a specific radioimmunoassay for moose and elk pregnancy-specific protein B. Journal of Wildlife Management 64(2): 492-499, 2000

Antenatal monitoring by pregnancy-specific beta 1 glycoprotein 125I radioimmunoassay. Zhonghua Fu Chan Ke Za Zhi 22(6): 329-31, 374, 1987