+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling

Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling

Oncotarget 8(16): 27166-27176

Epithelial ovarian carcinomas account for more than 90% of human ovarian cancers and have become the primary cause of death for gynecological malignancies. Unlimited cell proliferation and resistance to cell apoptosis contribute to the development of ovarian cancers. However, the underlying mechanisms involved in these processes in epithelial ovarian carcinomas are yet poorly understood. In the present study, we examined the Hippo signaling gene expression and investigated the effects of Sphingosine 1-phosphate (S1P) on cell proliferation and the underlying mechanisms in human ovarian cancer cell lines, OVCAR3 and SKOV3. Our results demonstrate that S1P disrupts Hippo signaling by reducing YAP phosphorylation and increasing the expression of CCN1 and CCN2 in both ovarian cancer cells. Furthermore, the increase in CCN1/CCN2 expression contributes to the S1P-induced increase in cancer cell proliferation.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 060270222

Download citation: RISBibTeXText

PMID: 28460443

Related references

Sphingosine-1-phosphate induces airway smooth muscle cell proliferation, migration, and contraction by modulating Hippo signaling effector YAP. American Journal of Physiology. Lung Cellular and Molecular Physiology 315(4): L609-L621, 2018

Wnt signaling promotes androgen-independent prostate cancer cell proliferation through up-regulation of the hippo pathway effector YAP. Biochemical and Biophysical Research Communications 486(4): 1034-1039, 2017

Long non-coding RNA LSINCT5 promotes ovarian cancer cell proliferation, migration and invasion by disrupting the CXCL12/CXCR4 signalling axis. Oncology Letters 15(5): 7200-7206, 2018

MiR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. International Journal of Oncology 52(3): 815-827, 2018

Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis. Medical Science Monitor 24: 1912-1923, 2018

Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis and Rheumatism 54(3): 742-753, 2006

ZNF280A Promotes Proliferation and Tumorigenicity via Inactivating the Hippo-Signaling Pathway in Colorectal Cancer. Molecular Therapy Oncolytics 12: 204-213, 2019

Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling. Cancer Research 70(22): 9197-9206, 2010

The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity. Plos one 3(3): E1761, 2008

Sphingosine 1-phosphate stimulates insulin secretion and promotes cell proliferation. Diabetes 48(Suppl. 1): A244, 1999

Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. Frontiers in Bioscience 22: 596-608, 2017

Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1Pr2. Frontiers in Bioscience 22(4): 596-608, 2017

Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway. Oncotarget 7(9): 10037-10050, 2016

DAXX promotes ovarian cancer ascites cell proliferation and migration by activating the ERK signaling pathway. Journal of Ovarian Research 11(1): 90, 2018

Sphingosine kinase 1 promotes glioma cell proliferation under hypoxia via calcium signaling. Nan Fang Yi Ke Da Xue Xue Bao 35(7): 1014-1018, 2015