+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Statin drug interactions and related adverse reactions: an update



Statin drug interactions and related adverse reactions: an update



Expert Opinion on Drug Safety 17(1): 25-37



Statins reduce the risk of cardiovascular morbidity and mortality in patients with or at risk for cardiovascular disease and their use is expanding, especially in elderly. Statins are prescribed on a long-term basis and may undergo drug-drug interactions (DDIs) with other drugs. Statins have different safety and tolerability, and this might affect the possibility of DDIs with other cardiovascular drugs, increasing the risk of statin-associated myopathy and hepatotoxicity. Polypharmacy and pharmacogenetic variability are potential causes of statin DDIs. Thus, the safety and adverse effects of statins, particularly in patients receiving multiple medications at risk of DDIs, are a matter of special concern. Areas covered: The purpose of this manuscript is to give an update on the potential statin DDIs and related adverse drug reactions (myopathy and hepatotoxicity), with special considerations on polypharmacy in elderly population, HIV patients, cardiovascular drugs and liver toxicities. The potential DDIs among statins and monoclonal antibodies including the recently approved PCSK9 inhibitors are also extensively discussed in the present review. Expert opinion: A better understanding of the incidence and clinical significance of statin DDIs will help physicians in fine-tuning the lipid-lowering therapeutic interventions thus providing their patients with an evidence-based, safe and cost-effective clinical support.

(PDF emailed within 0-6 h: $19.90)

Accession: 060276685

Download citation: RISBibTeXText

PMID: 29058944

DOI: 10.1080/14740338.2018.1394455


Related references

Statin drug interactions and related adverse reactions. Expert Opinion on Drug Safety 11(6): 933-946, 2013

Phenotyping Adverse Drug Reactions: Statin-Related Myotoxicity. AMIA Joint Summits on Translational Science Proceedings. AMIA Joint Summits on Translational Science 2015: 466-470, 2015

An update on adverse drug reactions related to β-lactam antibiotics. Expert Opinion on Drug Safety 17(5): 499-508, 2018

NSAID-related adverse drug interactions with clinical relevance. An update. International Journal of Clinical Pharmacology and Therapeutics 32(10): 509-532, 1994

Introduction of "the manual for handling disorders due to adverse drug reactions"--focus on the antibiotics related severe adverse drug reactions. Japanese Journal of Antibiotics 61(4): 269-288, 2008

Adverse Drug reactions in an Ageing PopulaTion (ADAPT) study protocol: a cross-sectional and prospective cohort study of hospital admissions related to adverse drug reactions in older patients. Bmj Open 7(6): E017322, 2018

Statin-associated psychiatric adverse events: A case/non case evaluation of an Italian database of spontaneous reporting of adverse drug reactions. 2007

Use of pharmacogenetic testing to prevent adverse drug reactions during statin therapy. Terapevticheskii Arkhiv 89(1): 82-87, 2017

Hospital-based survey of doctors' attitudes to adverse drug reactions and perception of drug-related risk for adverse reaction occurrence. Pharmacoepidemiology and Drug Safety 8 Suppl 1: S27-S35, 2004

Drug Adverse Reaction Target Database (DART) : proteins related to adverse drug reactions. Drug Safety 26(10): 685-690, 2003

Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department. Annals of Emergency Medicine 38(6): 666-671, 2001

Statin hepatotoxicity and the dilemma of causality in rare hepatic adverse drug reactions. Journal of Hepatology 57(3): 702-3; Author Reply 703-4, 2013

Association of adverse drug reactions with drug-drug and drug-disease interactions in frail older outpatients. Age and Ageing 40(2): 274-277, 2011

Drug skin tests and systemic cutaneous adverse drug reactions: an update. Expert Review of Dermatology 2(4): 481-495, 2007

Rhabdomyolysis after co-administration of a statin and fusidic acid: an analysis of the literature and of the WHO database of adverse drug reactions. British Journal of Clinical Pharmacology 84(5): 1057-1063, 2018