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Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis

Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis

Febs Open Bio 7(2): 174-186

The sweetener sucralose can signal through its GPCR receptor to induce insulin secretion from pancreatic β cells, but the downstream signaling pathways involved are not well-understood. Here we measure responses to sucralose, glucagon-like peptide 1, and amino acids in MIN6 β cells. Our data suggest a signaling axis, whereby sucralose induces calcium and cAMP, activation of ERK1/2, and site-specific phosphorylation of ribosomal protein S6. Interestingly, sucralose acted independently of mTORC1 or ribosomal S6 kinase (RSK). These results suggest that sweeteners like sucralose can influence β-cell responses to secretagogues like glucose through metabolic as well as GPCR-mediated pathways. Future investigation of novel sweet taste receptor signaling pathways in β cells will have implications for diabetes and other emergent fields involving these receptors.

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Accession: 060292621

Download citation: RISBibTeXText

PMID: 28174684

DOI: 10.1002/2211-5463.12172

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