Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

Song, B.; Yu, C.-B.; Ji, Y.; Chen, M.-W.; Zhou, Y.-G.

Chemical Communications 53(10): 1704-1707

2017


ISSN/ISBN: 1364-548X
PMID: 28102371
DOI: 10.1039/c6cc09493g
Accession: 060308653

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Abstract
A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Brønsted acid, giving a wide range of chiral γ-, δ-, and ε-sultams in high yields and up to 99% of enantioselectivity.