+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles

Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles

Journal of Controlled Release 248: 60-70

Acute inflammation is a protective response of the body to harmful stimuli, such as pathogens or damaged cells. However, dysregulated inflammation can cause secondary damage and could thus contribute to the pathophysiology of many diseases. Inflammasomes, the macromolecular complexes responsible for caspase-1 activation, have emerged as key regulators of immune and inflammatory responses. Therefore, modulation of inflammasome activity has become an important therapeutic approach. Here we describe the design of a smart nanodevice that takes advantage of the passive targeting of nanoparticles to macrophages and enhances the therapeutic effect of caspase-1 inhibitor VX-765 in vivo. The functional hybrid systems consisted of MCM-41-based nanoparticles loaded with anti-inflammatory drug VX-765 (S2-P) and capped with poly-L-lysine, which acts as a molecular gate. S2-P activity has been evaluated in cellular and in vivo models of inflammation. The results indicated the potential advantage of using nanodevices to treat inflammatory diseases.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 060314913

Download citation: RISBibTeXText

PMID: 28069553

DOI: 10.1016/j.jconrel.2017.01.002

Related references

Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles. Chemistry 21(44): 15506-15510, 2015

Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis. Nanoscale 10(19): 9141-9152, 2018

Multifunctional Peptide-Amphiphile End-Capped Mesoporous Silica Nanoparticles for Tumor Targeting Drug Delivery. Acs Applied Materials and Interfaces 9(3): 2093-2103, 2017

Controlled delivery using oligonucleotide-capped mesoporous silica nanoparticles. Angewandte Chemie 49(40): 7281-7283, 2010

Acetylcholinesterase-capped Mesoporous Silica Nanoparticles Controlled by the Presence of Inhibitors. Chemistry An Asian Journal 12(7): 775-784, 2017

Capped Mesoporous Silica Nanoparticles for the Selective and Sensitive Detection of Cyanide. Chemistry An Asian Journal 12(20): 2670-2674, 2017

Composite formation of Thiol-capped Au nanoparticles and mesoporous silica prepared by a sol-gel method. Journal of Materials Science 42(4): 1285-1292, 2007

Fluorogenic Sensing of Carcinogenic Bisphenol A using Aptamer-Capped Mesoporous Silica Nanoparticles. Chemistry 23(36): 8581-8584, 2017

Pseudorotaxane capped mesoporous silica nanoparticles for 3,4-methylenedioxymethamphetamine (MDMA) detection in water. Chemical Communications 53(25): 3559-3562, 2017

Targeted cargo delivery in senescent cells using capped mesoporous silica nanoparticles. Angewandte Chemie 51(42): 10556-10560, 2012

Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A. Chemistryopen 6(5): 653-659, 2017

Monitoring the Stimulated Uncapping Process of Gold-Capped Mesoporous Silica Nanoparticles. Analytical Chemistry 90(5): 3183-3188, 2018

Cathepsin-B induced controlled release from peptide-capped mesoporous silica nanoparticles. Chemistry 20(47): 15309-15314, 2014

Tumor Targeting and Tumor Growth Inhibition Capability of Mesoporous Silica Nanoparticles in Mouse Models. Enzymes 44: 61-82, 2018

Bioresponsive hyaluronic acid-capped mesoporous silica nanoparticles for targeted drug delivery. Chemistry 19(5): 1778-1783, 2013