+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Testicular Dose During Prophylaxis of Heterotopic Ossification with Radiation Therapy

Testicular Dose During Prophylaxis of Heterotopic Ossification with Radiation Therapy

In Vivo 31(3): 461-466

Label="AIM">A single-institution, retrospective study was performed to investigate potential techniques to minimize radiation exposure to the testicles during heterotopic ossification (HO) prophylaxis. We report the impact of split-beam technique (SBT) and different photon energies on the total dose of radiation received by the testicles during prophylaxis of HO.Label="MATERIALS AND METHODS">Between 2008 and 2010, we identified 64 patients with traumatic acetabular fractures who underwent surgery followed by radiation therapy (RT) without testicular shielding. Postoperative RT was delivered within 72 h in a single fraction of 700 cGy using 6-18 MV photons, without testicular shielding due to patient refusal. All patients underwent 3-D RT planning in which the testicles were contoured as a region of interest and dose-volume histograms (DVH) were generated. Additional treatment planning trials were created for each patient by utilizing a SBT medially and by using different photon energies (6, 10 and 18 MV) to study the effects of these maneuvers on the delivered dose to the testicles.Label="RESULTS">In reviewing the DVH, it was noted that the mean dose delivered to the testicles was 10 cGy (range=3-40). The maximum dose was 31 cGy (range=7-430). When SBT was utilized, a significant reduction in the mean (44%) and maximum (47%) doses delivered to the testicles was noted. Further reductions in the mean (26%) and maximum (14%) doses were achieved by using higher-energy (10-18 MV) beams. The radiation doses to the testicles from the CT simulation and the two portal images were estimated to be 4 and 1.5 cGy, respectively.Label="CONCLUSION">Low-dose prophylactic RT to prevent HO around the hip causes a low, but likely biologically meaningful, radiation dose to be delivered to the testicles. This dose could be further reduced by using a medial SBT and photon energies above 6 MV. Testicular shielding should be offered to all male patients receiving such RT. In addition, all patients should be informed about the consequences of testicular radiation as part of their informed consent.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 060321400

Download citation: RISBibTeXText

PMID: 28438880

Related references

Evaluation of scrotal and testicular radiation doses for heterotopic ossification prophylaxis. American Journal of Orthopedics 37(9): E163-E166, 2008

Reliable Radiation Technique to Minimize Ovarian Dose During Radiation Prophylaxis of Heterotopic Ossification. Anticancer Research 37(12): 6929-6935, 2017

Prophylaxis of heterotopic ossification in hip revisions with 7 Gy single-dose radiation. Zeitschrift für Orthopadie und ihre Grenzgebiete 140(3): 317-322, 2002

Radiation therapy for heterotopic ossification prophylaxis. Ugeskrift for Laeger 176(24):, 2014

Pattern of Failure of Heterotopic Ossification Around the Hip After Radiation Prophylaxis: Is It Time for Dose Painting?. International Journal of Radiation Oncology*biology*physics 93(3): E465-E466, 2015

Postsurgical radiation therapy for prophylaxis of heterotopic ossification. New Jersey Medicine 90(9): 672-674, 1993

Radiation Therapy Prophylaxis for Heterotopic Ossification of the Elbow Following Trauma or Recurrent HO. International Journal of Radiation Oncology*biology*physics 84(3): S623-S624, 2012

Is prophylaxis for heterotopic ossification with radiation therapy after THR associated with early loosening or carcinogenesis?. Hip International 2019: 1120700019842724, 2019

Shielding of the hip prosthesis during radiation therapy for heterotopic ossification is associated with increased failure of prophylaxis. International Journal of Radiation Oncology Biology Physics 67(5): 1499-1505, 2007

Indomethacin versus radiation therapy for prophylaxis against heterotopic ossification in acetabular fractures. The Journal of Bone and Joint Surgery. British volume 80-B(2): 259-263, 1998

Radiation therapy for recurrent heterotopic ossification prophylaxis after partial metatarsal amputation. Journal of Foot and Ankle Surgery 54(3): 345-349, 2015

Safety and efficacy of radiation therapy as secondary prophylaxis for heterotopic ossification of non-hip joints. Journal of Medical Imaging and Radiation Oncology 55(3): 333-336, 2011

Radiation therapy for heterotopic ossification prophylaxis afer high-risk elbow surgery. American Journal of Orthopedics 40(8): 400-405, 2011

Cancer risk estimates from radiation therapy for heterotopic ossification prophylaxis after total hip arthroplasty. Medical Physics 40(10): 101702, 2013

Radiation Therapy for Heterotopic Ossification Prophylaxis Acutely After Elbow Trauma: A Prospective Randomized Study. Year Book of Hand and Upper Limb Surgery 2011: 148-149, 2011