EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission


The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission



Plos Neglected Tropical Diseases 11(8): E0005800



ISSN/ISBN: 1935-2727

PMID: 28821017

DOI: 10.1371/journal.pntd.0005800

Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body. Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998-2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection. We examined 579 patients with 649 lesions; 32 (5.5%) patients had multiple lesions. Lesions were predominantly located on lower (70.0%) and upper (27.1%) limbs, and showed a non-random distribution with strong predilection for the ankles, elbows and calves. When stratified by gender, upper limb lesions were more common (OR 1·97, 95% CI 1·38-2·82, p<0·001) while lower limb lesions were less common in men than in women (OR 0·48, 95% CI 0·34-0·68, p<0·001). Patients aged ≥ 65 years (OR 3·13, 95% CI 1·52-6·43, p = 0·001) and those with a lesion on the ankle (OR 2·49, 95% CI 1·14-5·43, p = 0·02) were more likely to have multiple lesions. Most infections (71.3%) were likely acquired in the warmer 6 months of the year. Comparison with published work in Cameroon, Africa, showed similar lesion distribution and suggests the mode of M. ulcerans transmission may be the same across the globe. Our findings also aid clinical diagnosis and provide quantitative background information for further research investigating disease transmission.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 060363709

Download citation: RISBibTeXText

Related references

Microbiology of secondary infections in Buruli ulcer lesions; implications for therapeutic interventions. Bmc Microbiology 21(1): 4, 2021

Spatial Distribution of Mycobacterium ulcerans in Buruli Ulcer Lesions: Implications for Laboratory Diagnosis. Plos Neglected Tropical Diseases 10(6): E0004767, 2016

Ecology and transmission of Buruli ulcer disease: a systematic review. Plos Neglected Tropical Diseases 4(12): E911, 2010

Distribution of Buruli ulcer lesions over body surface area in a large case series in Ghana: uncovering clues for mode of transmission. Transactions of the Royal Society of Tropical Medicine and Hygiene 99(3): 196-201, 2005

In the case of transmission of Mycobacterium ulcerans in buruli ulcer disease Acanthamoeba species stand accused. Ghana Medical Journal 45(1): 31-34, 2011

Potential role for fish in transmission of Mycobacterium ulcerans disease (Buruli ulcer): an environmental study. Applied and Environmental Microbiology 70(9): 5679-5681, 2004

Developing a Buruli ulcer community of practice in Bankim, Cameroon: A model for Buruli ulcer outreach in Africa. Plos Neglected Tropical Diseases 12(3): E0006238, 2018

Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring. Plos Neglected Tropical Diseases 5(7): E1237, 2011

Socio-cultural determinants of timely and delayed treatment of Buruli ulcer: Implications for disease control. Infectious Diseases of Poverty 1(1): 6, 2012

Diagnostic Value of Histological Analysis of Punch Biopsies in Suspected Cutaneous Buruli Ulcer: A Study on 32 Cases of Confirmed Buruli Ulcer in Cameroon. Dermatopathology 6(2): 28-36, 2019

Former Buruli Ulcer Patients' Experiences and Wishes May Serve as a Guide to Further Improve Buruli Ulcer Management. PLoS neglected tropical diseases 10(12): e0005261, 2016

Associations between Mycobacterium ulcerans and aquatic plant communities of West Africa: implications for Buruli ulcer disease. Ecohealth 11(2): 184-196, 2014

Help-seeking for pre-ulcer and ulcer conditions of Mycobacterium ulcerans disease (Buruli ulcer) in Ghana. American Journal of Tropical Medicine and Hygiene 85(6): 1106-1113, 2011

Bacterial diversity in Buruli ulcer skin lesions: Challenges in the clinical microbiome analysis of a skin disease. Plos one 12(7): E0181994, 2017

Buruli ulcer and its bone lesions: concerning 73 cases. Bulletin des Seances, Academie Royale des Sciences d' Outre Mer 49(2): 161-190, 2003