+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The role of rare innate immune cells in Type 2 immune activation against parasitic helminths

The role of rare innate immune cells in Type 2 immune activation against parasitic helminths

Parasitology 144(10): 1288-1301

The complexity of helminth macroparasites is reflected in the intricate network of host cell types that participate in the Type 2 immune response needed to battle these organisms. In this context, adaptive T helper 2 cells and the Type 2 cytokines interleukin (IL)-4, IL-5, IL-9 and IL-13 have been the focus of research for years, but recent work has demonstrated that the innate immune system plays an essential role. Some innate immune cells that promote Type 2 immunity are relatively abundant, such as macrophages and eosinophils. However, we now appreciate that more rare cell types including group 2 innate lymphoid cells, basophils, mast cells and dendritic cells make significant contributions to these responses. These cells are found at low frequency but they are specialized to their roles - located at sites such as the skin, lung and gut, where the host combats helminth parasites. These cells respond rapidly and robustly to worm antigens and worm-induced damage to produce essential cytokines, chemokines, eicosanoids and histamine to activate damaged epithelium and to recruit other effectors. Thus, a greater understanding of how these cells operate is essential to understand how the host protects itself during helminth infection.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 060386948

Download citation: RISBibTeXText

PMID: 28583216

DOI: 10.1017/s0031182017000488

Related references

A role for BLyS in the activation of innate immune cells. Blood 108(8): 2687-2694, 2006

The innate immune responses of colonic epithelial cells to Trichuris muris are similar in mouse strains that develop a type 1 or type 2 adaptive immune response. Infection and Immunity 74(11): 6280-6286, 2006

Innate immune sensing 2.0 - from linear activation pathways to fine tuned and regulated innate immune networks. Experimental Dermatology 21(1): 61-69, 2012

Innate immune sensing 2 – from linear activation pathways to fine tuned and regulated innate immune networks. 2012

A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus. Channels 8(2): 131-141, 2014

Role of interleukin-33 in innate-type immune cells in allergy. Allergology International 62(1): 13-20, 2013

Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes. European Journal of Immunology 40(9): 2506-2516, 2010

Role of innate immune cells in metabolism: from physiology to type 2 diabetes. Seminars in Immunopathology 41(4): 531-545, 2019

Experimental food allergy models to study the role of innate immune cells as initiators of allergen-specific Th2 immune responses. Drug Discovery Today: Disease Models 17-18: 55-62, 2015

The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems. Plos one 7(2): E32125, 2012

Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation. Mediators of Inflammation 2017: 6059203, 2017

Altered expression of talin 1 in peripheral immune cells points to a significant role of the innate immune system in spontaneous autoimmune uveitis. Journal of Proteomics 75(14): 4536-4544, 2012

Major fundamental factors hindering immune system in defense against tumor cells: The link between insufficiency of innate immune responses, metabolism, and neurotransmitters with effector immune cells disability. Immunology Letters 212: 81-87, 2019

On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites. Cellular Microbiology 10(9): 1757-1764, 2008

A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis. Journal of Immunology 198(1): 128-137, 2017