+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The Usefulness of Phospholipase A2 Receptor and IgG4 Detection in Differentiation Primary Membranous Nephropathy From Secondary Membranous Nephropathy in Renal Biopsy



The Usefulness of Phospholipase A2 Receptor and IgG4 Detection in Differentiation Primary Membranous Nephropathy From Secondary Membranous Nephropathy in Renal Biopsy



Applied Immunohistochemistry and Molecular Morphology 26(8): 591-598



Membranous nephropathy (MGN) is the most common cause of the nephrotic syndrome in adults. Most cases of MGN are primary, but secondary MGN are frequently encountered. Determination of secondary MGN is crucial for initiation of appropriate treatment. The diagnostic performance of the phospholipase A2 receptor (PLA2R) and immunoglobulin G4 (IgG4) detection based on immunohistochemistry were evaluated using biopsy tissues of 59 primary and 56 secondary MGN cases for discrimination between primary MGN and secondary MGN. The PLA2R and IgG4 detection based on immunohistochemistry were dominantly positive in primary MGN cases. Sensitivity and specificity values for identification of primary MGN were 83% and 88% for PLA2R, and 76% and 86% for IgG4. Both PLA2R and IgG4 positivity showed a high specificity of 96.4% for identifying primary MGN. A meta-analysis was performed for analysis of the diagnostic accuracy of histologic PLA2R and IgG4 deposition for differentiation of primary from secondary MGN. The overall sensitivity, specificity, and area under curve of summary receiver operating characteristics were 76%, 86%, 0.93 for histologic PLA2R deposition, and 80%, 69%, 0.82 for histologic IgG4 deposition. PLA2R and IgG4 detection based on immunohistochemistry can be useful for differentiation of primary MGN from secondary MGN.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 060395664

Download citation: RISBibTeXText

PMID: 28362702

DOI: 10.1097/pai.0000000000000460


Related references

Expression of phospholipase A2 receptor and IgG4 in patients with membranous nephropathy. Vascular Health and Risk Management 14: 103-108, 2018

M-type phospholipase A2 receptor autoantibodies and renal function in patients with primary membranous nephropathy. Clinical Journal of the American Society of Nephrology 9(11): 1883-1890, 2015

Phospholipase A2 receptor-associated membranous nephropathy in a patient with IgG4-related disease: A case report. Medicine 98(20): E15616, 2019

Complement c 5b 9 complex is found in subepithelial deposits of stage i idiopathic membranous nephropathy but not of stage i de novo membranous nephropathy and toxic induced membranous nephropathy. Kidney International 26(4): 633, 1984

Circulating antibodies to α-enolase and phospholipase A 2 receptor and composition of glomerular deposits in Japanese patients with primary or secondary membranous nephropathy. Clinical and Experimental Nephrology 21(1): 117-126, 2016

Kimura's disease associated with membranous nephropathy with IgG4 and phospholipase A2 receptor-positive staining of the glomerular basement membrane. Internal Medicine 53(13): 1435-1440, 2015

Association of podocyte autophagosome numbers with idiopathic membranous nephropathy and secondary membranous nephropathy. International Urology and Nephrology 49(6): 1025-1031, 2017

Immunohistochemical Glomerular Expression of Phospholipase A2 Receptor in Primary and Secondary Membranous Nephropathy: A Retrospective Study in an Indian Cohort with Clinicopathological Correlations. Nephron Extra 7(1): 1-9, 2017

Patients With Combined Membranous Nephropathy and Focal Segmental Glomerulosclerosis Have Comparable Clinical and Autoantibody Profiles With Primary Membranous Nephropathy: A Retrospective Observational Study. Medicine 95(21): E3786, 2017

Renal phospholipase A2 receptor in hepatitis B virus-associated membranous nephropathy. American Journal of Nephrology 41(4-5): 345-353, 2016

IgG4 anti-phospholipase A2 receptor might activate lectin and alternative complement pathway meanwhile in idiopathic membranous nephropathy: an inspiration from a cross-sectional study. Immunologic Research 64(4): 919-930, 2017

Diagnostic value of renal phospholipase A2 receptor and serum anti-phospholipase A2 receptor antibody in membranous nephropathy. Zhong Nan Da Xue Xue Bao. Yi Xue Ban 42(4): 395-399, 2017

Renal Phospholipase A2 Receptor and the Clinical Features of Idiopathic Membranous Nephropathy. Chinese Medical Journal 130(8): 892-898, 2017

Anti-Phospholipase A2 Receptor Autoantibody: A New Biomarker for Primary Membranous Nephropathy. Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry 16(1): 4-17, 2016

Anti-phospholipase A2 receptor antibodies in primary membranous nephropathy-10 key points. Nephrology, Dialysis, Transplantation 33(2): 212-213, 2018