The Use of Multinutrient Human Milk Fortifiers in Preterm Infants: A Systematic Review of Unanswered Questions

Mimouni, F.B.; Nathan, N.; Ziegler, E.E.; Lubetzky, R.; Mandel, D.

Clinics in Perinatology 44(1): 173-178


ISSN/ISBN: 0095-5108
PMID: 28159204
DOI: 10.1016/j.clp.2016.11.011
Accession: 060396504

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There is evidence that multinutrient fortification of human milk increases in-hospital growth of preterm infants, but fortification has not been shown to improve long-term growth and neurodevelopmental outcome. We aimed to ascertain whether randomized controlled trials have determined the effect of early versus late introduction of fortifiers on growth and/or other outcomes, and have compared the efficacy/adverse effects of human milk-based versus cow milk-based fortifiers. We conclude that there is little evidence that early introduction of human milk fortification affects important outcomes, and limited evidence that a bovine fortifier places the infant at a higher risk of NEC.