+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Transient Elastography (FibroScan) Performs Better Than Non-Invasive Markers in Assessing Liver Fibrosis and Cirrhosis in Autoimmune Hepatitis Patients



Transient Elastography (FibroScan) Performs Better Than Non-Invasive Markers in Assessing Liver Fibrosis and Cirrhosis in Autoimmune Hepatitis Patients



Medical Science Monitor 23: 5106-5112



BACKGROUND Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease that can lead to severe fibrosis and cirrhosis. Transient elastography (TE, FibroScan) can assess the fibrotic stages of chronic liver diseases by liver stiffness measurement (LSM). Studies on the diagnostic accuracy of FibroScan for the detection of fibrosis in AIH patients are still limited. MATERIAL AND METHODS This study enrolled 108 AIH patients who underwent liver biopsies. Using the METAVIR scoring system as the reference, Spearman's rank correlation was performed to explore the relationship between the markers and stages of fibrosis. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the diagnostic accuracy. The optimal LSM cut-off values for predicting the stages of fibrosis were calculated. RESULTS LSM was superior to other non-invasive markers in differentiating the stages of fibrosis in AIH patients. AUROC value of LSM was 0.885 for stage F2, 0.897 for stage F3, and 0.878 for stage F4. The optimal LSM cut-off value was 6.27 kPa for stage F2, 8.18 kPa for F3, and 12.67 kPa for F4. CONCLUSIONS FibroScan is a valuable non-invasive method for the evaluation of liver fibrosis of AIH patients.

(PDF emailed within 1 workday: $29.90)

Accession: 060417293

Download citation: RISBibTeXText

PMID: 29073121


Related references

Comparison of surrogate serum markers and transient elastography (Fibroscan) for assessing cirrhosis in patients with chronic viral hepatitis. Digestive Diseases and Sciences 55(12): 3552-3560, 2011

Sa1010 The Role of Transient Elastography in Assessing Significant Liver Fibrosis and Cirrhosis in Patients With Chronic Liver Disease: An Evaluation of MRE and FibroScan in Hepatology Clinics. Gastroenterology 148(4): S-1005-S-1006, 2015

Evaluation of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis. Journal of Gastroenterology and Hepatology 32(3): 639-644, 2016

Non-invasive assessment of portal hypertension in patients with liver cirrhosis using FibroScan transient elastography. Zhonghua Gan Zang Bing Za Zhi 21(11): 840-844, 2014

Development of a non-invasive algorithm with transient elastography (Fibroscan) and serum test formula for advanced liver fibrosis in chronic hepatitis B. Alimentary Pharmacology and Therapeutics 31(10): 1095-1103, 2010

Evaluation of the costs of transient elastography (FibroScan(®)) in the diagnosis of liver fibrosis in HIV patients with hepatitis C virus. Enfermedades Infecciosas Y Microbiologia Clinica 30(6): 294-299, 2012

Performance of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome. World Journal of Gastroenterology 24(6): 737-743, 2018

Validation of transient elastography (Fibroscan) in assessment of hepatic fibrosis in autoimmune hepatitis. Zhonghua Gan Zang Bing Za Zhi 19(10): 782-784, 2012

Diagnosis of liver fibrosis by transient elastography (FibroScan) and non-invasive methods in Crohn's disease patients treated with methotrexate. Alimentary Pharmacology & Therapeutics 23(11): 1621-1628, 2006

Performance and Utility of Transient Elastography and Non-Invasive Markers of Liver Fiibrosis in Patients with Autoimmune Hepatitis: A Single Centre Experience. Hepatitis Monthly 16(11): E40737, 2017

Transient elastography (FibroScan) for non-invasive assessment of liver fibrosis. Issues in Emerging Health Technologies 2006(90): 1-4, 2006

AB0784Two no-invasive methods to evaluate liver fibrosis in systemic sclerosis patients: Transient elastography (fibroscan) and APRI score. Annals of the Rheumatic Diseases 71(Suppl 3): 683.8-683, 2013

Diagnostic accuracy of transient elastography (FibroScan) versus the aspartate transaminase to platelet ratio index in assessing liver fibrosis in chronic hepatitis B: the role in primary care setting. Journal of Clinical Pathology 64(10): 916-920, 2011

Noninvasive assessment of liver fibrosis. Serum markers and transient elastography (FibroScan). Revista Espanola de Enfermedades Digestivas 101(11): 787-799, 2010

Transient elastography (FibroScan) for the non-invasive assessment of liver fibrosis: current status and perspectives. Zeitschrift für Gastroenterologie 45(5): 387-394, 2007