+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Tumor Infiltrating Lymphocytes (TILs) May be Only an Independent Predictor of Nodal Involvement but not for Recurrence and Survival in Cutaneous Melanoma Patients



Tumor Infiltrating Lymphocytes (TILs) May be Only an Independent Predictor of Nodal Involvement but not for Recurrence and Survival in Cutaneous Melanoma Patients



Cancer Investigation 35(8): 501-505



Tumor infiltrating lymphocytes (TILs) invade and disrupt melanoma cells and their clinical roles remain controversial. In this study, we aimed to determine the clinical significance of the TILs status in cutaneous melanoma patients (CMPs). Of 750 CMPs enrolled into this study 486 (64.8%) had lesions with TILs. The patients with TILs more likely had nodular histology, presence of histological regression, and absence of regional lymph node involvement. However, its presence was not associated with outcome. In conclusion, presence of TILs may be only an independent predictor for absence of nodal involvement but it is not associated with recurrence and survival in CMPs.

(PDF emailed within 0-6 h: $19.90)

Accession: 060429851

Download citation: RISBibTeXText

PMID: 28799813

DOI: 10.1080/07357907.2017.1351984


Related references

Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma. Journal of Clinical Oncology 30(21): 2678-2683, 2012

Histological lymphovascular invasion is associated with nodal involvement, recurrence, and survival in patients with cutaneous malignant melanoma. International Journal of Dermatology (): -, 2016

Chemosensitivity, tumor infiltrating lymphocytes (TILs), and survival of postpartum PABC patients treated by neoadjuvant chemotherapy. Breast 42: 61-67, 2018

T helper cells in melanoma tumor infiltrating lymphocytes tils. Proceedings of the American Association for Cancer Research Annual Meeting 32: 238, 1991

Expansion and characterization of human melanoma tumor-infiltrating lymphocytes (TILs). Plos One 5(11): E13940-E13940, 2011

No effect of tumor-infiltrating lymphocytes (TILs) on prognosis in patients with early triple-negative breast cancer: Validation of recommendations by the International TILs Working Group 2014. Journal of Surgical Oncology 114(1): 17-21, 2016

Aberrant NEK2 expression might be an independent predictor for poor recurrence-free survival and overall survival of skin cutaneous melanoma. European Review for Medical and Pharmacological Sciences 22(12): 3694-3702, 2018

Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma. Cancer Immunity 9: 3-3, 2009

Tumor-infiltrating lymphocytes predict cutaneous melanoma survival. Melanoma Research 25(4): 306-311, 2016

Reproducible evaluation of tumor-infiltrating lymphocytes (TILs) using the recommendations of International TILs Working Group 2014. Annals of Diagnostic Pathology 35: 77-79, 2018

The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. Annals of Oncology 26(2): 259-271, 2016

Interobserver Agreement Between Pathologists Assessing Tumor-Infiltrating Lymphocytes (TILs) in Breast Cancer Using Methodology Proposed by the International TILs Working Group. Annals of Surgical Oncology 23(7): 2242-2248, 2018

Tumor-infiltrating lymphocytes (TILs) from patients with glioma. Oncoimmunology 6(2): E1252894-E1252894, 2017

High percentage of ADAM-10 positive melanoma cells correlates with paucity of tumor-infiltrating lymphocytes but does not predict prognosis in cutaneous melanoma patients. Analytical Cellular Pathology 2015: 975436-975436, 2016

SMAD7 is a novel independent predictor of survival in patients with cutaneous melanoma. Translational Research 2018: -, 2018