+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Vitamin D analogues: Potential use in cancer treatment

Vitamin D analogues: Potential use in cancer treatment

Critical Reviews in Oncology/Hematology 112: 190-197

The vitamin D receptor (VDR) is a member of the thyroid-steroid family of nuclear transcription factors. Following binding of the active form of vitamin D, i.e., 1,25(OH)2D3 (also known as calcitriol) and interaction with co-activators and co-repressors, VDR regulates the expression of several different genes. Although relatively little work has been carried out on VDR in human cancers, several epidemiological studies suggest that low circulating levels of vitamin D are associated with both an increased risk of developing specific cancer types and poor outcome in patients with specific diagnosed cancers. These associations apply especially in colorectal and breast cancer. Consistent with these findings, calcitriol as well as several of its synthetic analogues have been shown to inhibit tumor cell growth in vitro and in diverse animal model systems. Indeed, some of these vitamin D analogues with low calcemic inducing activity (e.g., EB1089, inecalcitol, paricalcitol) have progressed to clinical trials in patients with cancer. Preliminary results from these trials suggest that these vitamin D analogues have minimal toxicity, but clear evidence of efficacy remains to be shown. Although evidence of efficacy for mono-treatment with vitamin D analogues is currently lacking, several studies have reported that supplementation with calcitriol or the presence of high endogenous circulating levels of vitamin D enhances response to standard therapies.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 060466466

Download citation: RISBibTeXText

PMID: 28325259

DOI: 10.1016/j.critrevonc.2017.02.015

Related references

Novel vitamin D-3 analogues and their potential for inhibiting cancer cell growth. Drugs of the Future 18(11): 1057-1061, 1993

Vitamin E analogues and immune response in cancer treatment. Vitamins and Hormones 76: 463-491, 2007

The potential use of somatostatin analogues in the treatment of cancer. Journal Of Endocrinology 121(3 Suppl), 1989

Therapeutic Potential of Thalidomide and Its Analogues in the Treatment of Cancer. Anticancer Research 35(11): 5767-5772, 2015

Potential role of somatostatin analogues in the treatment of cancer. European Journal of Clinical Investigation 17(4): 281-287, 1987

Synthesis of oxa analogues of vitamin d the design of potential inhibitors of vitamin d metabolism. Abstracts of Papers American Chemical Society 194: MEDI 13, 1987

Inhibition of breast cancer cell growth by combined treatment with vitamin D3 analogues and tamoxifen. Cancer Research 54(21): 5711-5717, 1994

The potential role of somatostatin analogues in breast cancer treatment. Yale Journal of Biology and Medicine 70(5-6): 535-539, 1998

Vitamin d analogues potential inhibitors of vitamin d metabolism. Norman, A W , Et Al (Ed ) Vitamin D: Molecular, Cellular And Clinical Endocrinology; Seventh Workshop on Vitamin D, Rancho Mirage, California, Usa, April 24-29, Xxxix+1071p Walter De Gruyter And Co : Berlin, West Germany; New York, New York, Usa Illus 12-21, 1988

The discovery of new and more potent chloropyramine (C4) analogues for the potential treatment of invasive breast cancer. Chemical Biology and Drug Design 91(1): 314-321, 2018

Control of proliferating potential of myeloid leukemia cells during long-term treatment with vitamin D3 analogues and other differentiation inducers in combination with antileukemic drugs: in vitro and in vivo studies. Cancer Research 47(2): 567-572, 1987

Vitamin D3 and vitamin D3 analogues as an adjunct to cancer chemo-therapy and radiotherapy. Current Medicinal Chemistry. Anti-Cancer Agents 2(6): 683-690, 2002

Potential application of curcumin and its analogues in the treatment strategy of patients with primary epithelial ovarian cancer. International Journal of Molecular Sciences 15(12): 21703-21722, 2014

Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Molecular Cancer Therapeutics 5(10): 2563-2571, 2006

Vitamin D analogues are more potent activators of vitamin D response elements than the native hormone in colon cancer cells. Gut 40(Suppl. 1): A78, 1997