+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Whole-Body SPECT/CT versus Planar Bone Scan with Targeted SPECT/CT for Metastatic Workup



Whole-Body SPECT/CT versus Planar Bone Scan with Targeted SPECT/CT for Metastatic Workup



Biomed Research International 2017: 7039406



The use of SPECT/CT in bone scans has been widespread in recent years, but there are no specific guidelines concerning the optimal acquisition protocol. Two strategies have been proposed: targeted SPECT/CT for equivocal lesions detected on planar images or systematic whole-body SPECT/CT. Our aim was to compare the diagnostic accuracy of the two approaches. 212 consecutive patients with a history of cancer were referred for bone scans to detect bone metastases. Two experienced readers randomly evaluated for each patient either planar images with one-field SPECT/CT targeted on equivocal focal uptakes (targeted SPECT/CT) or a whole-body (two-field) SPECT/CT acquisition from the base of the skull to the proximal femurs (whole-body SPECT/CT). The exams were categorized as "nonmetastatic," "equivocal," or "metastatic" on both protocols. The presence or absence of any extra-axial skeletal lesions was also assessed. The sensitivity and specificity of both strategies were measured using the results of subsequent imaging follow-up as the reference standard. Whole-body SPECT/CT had a significantly higher sensitivity than targeted SPECT/CT to detect bone metastases (p = 0.0297) and to detect extra-axial metastases (p = 0.0266). There was no significant difference in specificity among the two approaches. Whole-body SPECT/CT is the optimal modality of choice for metastatic workup, including detection of extra-axial lesions, with improved sensitivity and similar specificity compared to targeted SPECT/CT.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 060477308

Download citation: RISBibTeXText

PMID: 28812019

DOI: 10.1155/2017/7039406


Related references

Prospective evaluation of planar bone scintigraphy, SPECT, SPECT/CT, 18F-NaF PET/CT and whole body 1.5T MRI, including DWI, for the detection of bone metastases in high risk breast and prostate cancer patients: SKELETA clinical trial. Acta Oncologica 55(1): 59-67, 2016

A prospective study comparing whole-body FDG PET/CT to combined planar bone scan with 67Ga SPECT/CT in the Diagnosis of Spondylodiskitis. Clinical Nuclear Medicine 37(9): 827-832, 2012

Pulmonary alveolar microlithiasis: imaging characteristics of planar and SPECT/CT bone scan versus 18F-FDG and 18F-sodium fluoride PET/CT scanning. Japanese Journal of Radiology 31(11): 766-769, 2013

Characterization of focal bone lesions in the axial skeleton: performance of planar bone scintigraphy compared with SPECT and SPECT fused with CT. Ajr. American Journal of Roentgenology 188(5): W467-W474, 2007

Metastases seen on SPECT imaging despite a normal planar bone scan. Clinical Nuclear Medicine 20(12): 1052-1054, 1995

SPECT versus planar liver scintigraphy: is SPECT worth it?. Journal of Nuclear Medicine 30(1): 57-59, 1989

Incremental value of 99m Tc-HYNIC-TOC SPECT/CT over whole-body planar scintigraphy and SPECT in patients with neuroendocrine tumours. Nuklearmedizin. Nuclear Medicine 56(3): 97, 2017

Indeterminate lesions on planar bone scintigraphy in lung cancer patients: SPECT, CT or SPECT-CT?. Skeletal Radiology 41(7): 843-850, 2012

Utility of (99m)Tc-MDP hybrid SPECT-CT for diagnosis of skull base osteomyelitis: comparison with planar bone scintigraphy, SPECT, and CT. Japanese Journal of Radiology 31(2): 81-88, 2013

Should SPECT-CT replace SPECT for the evaluation of equivocal bone scan lesions in patients with underlying malignancies?. Nuclear Medicine Communications 31(7): 659-665, 2010

Advantages of systematic trunk SPECT/CT to planar bone scan (PBS) in more than 300 patients with breast or prostate cancer. Oncotarget 9(60): 31744-31752, 2018

Differentiated thyroid carcinoma: Incremental diagnostic value of 131 I SPECT/CT over planar whole body scan after radioiodine therapy. Endocrine 56(3): 551-559, 2017

A Comparison of Accuracy of Planar and Evolution SPECT/CT Bone Imaging in Differentiating Benign from Metastatic Bone Lesions. Journal of the Medical Association of Thailand 100(1): 100-110, 2017

Three-minute SPECT/CT is sufficient for the assessment of bone metastasis as add-on to planar bone scintigraphy: prospective head-to-head comparison to 11-min SPECT/CT. Ejnmmi Research 7(1): 1, 2017

Efficacy of SPECT over planar bone scan in the diagnosis of solitary vertebral lesions in patients with low back pain. Indian Journal of Nuclear Medicine 25(2): 44-48, 2010