+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Zygotic Genome Activation in Vertebrates



Zygotic Genome Activation in Vertebrates



Developmental Cell 42(4): 316-332



The first major developmental transition in vertebrate embryos is the maternal-to-zygotic transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins. During the MZT, the embryo takes charge of gene expression to control cell differentiation and further development. This spectacular organismal transition requires nuclear reprogramming and the initiation of RNAPII at thousands of promoters. Zygotic genome activation (ZGA) is mechanistically coordinated with other embryonic events, including changes in the cell cycle, chromatin state, and nuclear-to-cytoplasmic component ratios. Here, we review progress in understanding vertebrate ZGA dynamics in frogs, fish, mice, and humans to explore differences and emphasize common features.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 060486163

Download citation: RISBibTeXText

PMID: 28829942

DOI: 10.1016/j.devcel.2017.07.026


Related references

Phosphorylation of RNA polymerase II largest subunit upon zygotic genome activation in vertebrates. International Journal of Developmental Biology 40(3): 21S, 1996

Mouse Xist expression begins at zygotic genome activation and is timed by a zygotic clock. Molecular Reproduction and Development 61(1): 14-20, 2002

The maternal-zygotic transition and zygotic activation of the Mnemiopsis leidyi genome occurs within the first three cleavage cycles. Molecular Reproduction and Development 84(11): 1218-1229, 2017

Zygotic genome activation during the maternal-to-zygotic transition. Annual Review of Cell and Developmental Biology 30: 581-613, 2014

Identification of early zygotic genes in the yellow fever mosquito Aedes aegypti and discovery of a motif involved in early zygotic genome activation. Plos One 7(3): E33933-E33933, 2012

Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science 341(6149): 1005-1009, 2013

Mammalian zygotic genome activation. Seminars in Cell and Developmental Biology 84: 118-126, 2018

The timing of zygotic genome activation. Current Opinion in Genetics and Development 43: 53-60, 2017

Transcriptional Activation of the Zygotic Genome in Drosophila. Current Topics in Developmental Biology 113: 85, 2015

A histone timer for zygotic genome activation. Developmental Cell 26(6): 558-559, 2013

Origin of new genes after zygotic genome activation in vertebrate. Journal of Molecular Cell Biology 10(2): 139-146, 2018

Cohesin facilitates zygotic genome activation in zebrafish. Development 145(1):, 2018

Chromatin-linked determinants of zygotic genome activation. Cellular and Molecular Life Sciences 70(8): 1425-1437, 2013

Zygotic Genome Activation Occurs Shortly after Fertilization in Maize. Plant Cell 29(9): 2106-2125, 2017

Zygotic Genome Activation Revisited: Looking Through the Expression and Function of Zscan4. Current Topics in Developmental Biology 120: 103-124, 2016