Studies on the in vivo metabolism of lipoic acid. I. The fate of dl-lipoic acid -S35 in normal and thiamine-deficient rats

Emery, M. Gal; Dzidra, E. Razevska

Archives of Biochemistry and Biophysics 89(2): 253-261


ISSN/ISBN: 0003-9861
DOI: 10.1016/0003-9861(60)90051-5
Accession: 061012895

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The in vivo distribution, utilization, and rate of elimination of lipoic acid-S35, both in normal and thiamine-deficient rats, was investigated. About 40% of the activity was recovered in 24-hr. urine, with 90% of the activity in the total sulfur fraction. Of the injected dl-lipoic acid, 9% was excreted as such, 34% of which was in the (+) form as determined by microbiological assay. Blood, spleen, and liver of the deficient animals yielded greater recovery of activity. Intraperitoneal injection of dl-lipoic acid was toxic to deficient animals but, unlike neopyrithiamine, had no effect on thiamine excretion.