Alterations in rat liver microsomal and lysosomal β-glucuronidase by compounds which induce hepatic drug-metabolizing enzymes
Lucier, G W.; McDaniel, O S.
Biochimica et Biophysica Acta - General Subjects 261(1): 168-176
ISSN/ISBN: 0304-4165 DOI: 10.1016/0304-4165(72)90326-1
Chlordane, dieldrin, piperonyl butoxide, and benzpyrene, which induce the hepatic microsomal mixed function oxidases and Udp glucuronyltransferases, decreased activity of smooth and rough endoplasmic reticulum β-glucuronidase. The reduction occurred when either p-nitrophenyl β-D-glucuronide or phenolphthalein mono-β-glucuronide was used as the substrate.