Effect of Cb-154 (2-Br- -Ergocryptine) on Serum Follicle Stimulating Hormone, Luteinizing Hormone and Prolactin in Women with the Amenorrhoea-Galactorrhoea Syndrome
Seki, K.; Seki, M.; Okumura, T.
European Journal of Endocrinology 79(1): 25-33
ISSN/ISBN: 0804-4643 DOI: 10.1530/acta.0.0790025
Four women with the amenorrhoea-galactorrhoea syndrome were treated with 2-Br-a-ergocryptine (CB-154). In 3 patients, lactation was inhibited and ovulation was induced. Furthermore, pregnancy was achieved in one of them. In the remaining case, neither was lactation inhibited nor ovulation induced. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) were measured sequentially in the 4 CB- 154 treated women. They showed high serum PRL levels and acyclic patterns of serum FSH and LH. CB-154 suppressed PRL secretion and stimulated FSH and LH secretion in 3 cases where lactation was inhibited and ovulation was induced.