Effect of prostaglandin E1 on the adenyl cyclase-cyclic AMP system and gluconeogenesis in rat renal cortical slices
Morrison, A; Yates, J; Klahr, S
Biochimica et Biophysica Acta - General Subjects 421(2): 203-209
ISSN/ISBN: 0304-4165 DOI: 10.1016/0304-4165(76)90286-5
Prostaglandin E1 was found to increase the formation of cyclic adenosine 3t́,5t́-monophosphate (cyclic AMP) by renal cortical slices. This increased release of cyclic Amp was not influenced by the absence of Ca2+ in the incubating media. The enhanced production of cyclic Amp was probably mediated by stimulation of membrane-bound adenylate cyclase activity. An increase in adenyl cyclase activity was observed with increasing concentrations of prostaglandin E1.