Section 62
Chapter 61,847

The pharmacokinetics of α-methyldopa in dogs

Gregory, M. Kochak; William, D. Mason

Journal of Pharmacokinetics and Pharmacodynamics 13(4): 405-423


ISSN/ISBN: 1567-567X
DOI: 10.1007/bf01061477
Accession: 061846965

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alpha-Methyldopa was intraarterially and orally administered to dogs at two dose levels in a randomized complete crossover design. The appearance of secondary peaks in the plasma concentration-time profiles indicated the presence of enterohepatically recycled methyldopa. This was established by the absence of a secondary peak following readministration of a dose after biliary cannulation and the detection of methyldopa in the bile of a cannulated dog.

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