Section 62
Chapter 61,984

Frequency-Dependence of 3H-Noradrenaline Release from Rabbit Pulmonary Artery: Effect of α-Adrenoceptor Antagonists and Inhibitors of Transmitter Inactivation

Ove, A. Nedergaard

Basic and Clinical Pharmacology and Toxicology 63(5): 317-323


ISSN/ISBN: 1742-7835
DOI: 10.1111/j.1600-0773.1988.tb00961.x
Accession: 061983316

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The aim of this study was to examine the modulating role of presynaptic alpha 2-adrenoceptors on transmitter release from vascular sympathetic neurones. This was done by examining the influence of removal of inactivation pathways on the effect of alpha-adrenoceptor antagonists on the release of transmitter from noradrenergic neurones. The rabbit main pulmonary artery preloaded with 3H-noradrenaline (3H-NA) was used.

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