Frequency-Dependence of 3H-Noradrenaline Release from Rabbit Pulmonary Artery: Effect of α-Adrenoceptor Antagonists and Inhibitors of Transmitter Inactivation
Ove, A. Nedergaard
Basic and Clinical Pharmacology and Toxicology 63(5): 317-323
ISSN/ISBN: 1742-7835 DOI: 10.1111/j.1600-0773.1988.tb00961.x
The aim of this study was to examine the modulating role of presynaptic alpha 2-adrenoceptors on transmitter release from vascular sympathetic neurones. This was done by examining the influence of removal of inactivation pathways on the effect of alpha-adrenoceptor antagonists on the release of transmitter from noradrenergic neurones. The rabbit main pulmonary artery preloaded with 3H-noradrenaline (3H-NA) was used.