Tablet-tablet contact and mutual rubbing within a coating drum an important factor governing the properties and appearance of tablet film coatings

Rowe, R.C.

International Journal of Pharmaceutics 43(1): 155-159

1988


ISSN/ISBN: 0378-5173
DOI: 10.1016/0378-5173(88)90070-1
Accession: 062009958

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Abstract
Surface roughness measurements taken over the exposed surface and within the intagliation of a film coated tablet have shown that the roughness within the intagliation is always higher than that on the exposed surface. This effect has been interpreted in terms of the magnitude of the shear stresses induced by surface tension forces and mutual rubbing due to tablet-tablet contact within the coating drum. The implications of these findings in the applicability of using sprayed free films as models for tablet film coatings is discussed.