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Temperature dependence and thermodynamics of partitioning of clofazimine analogues in the n-octanol/water system



Temperature dependence and thermodynamics of partitioning of clofazimine analogues in the n-octanol/water system



International Journal of Pharmaceutics 58(2): 107-113



The partition coefficient of eight N2-substituted phenazines was measured at four temperatures (range 20-55.degree. C) in the n-octanol/water system. The apparent molal partition coefficients K'M, were calculated from the distribution results. Plots of log Km vs. T-1 were linear and the thermodynamic parameters for the solute transfer were evaluated from the Van't Hoff isochore.

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Accession: 062133421

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DOI: 10.1016/0378-5173(90)90247-2


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