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α1 (but not α2) -Adrenoceptor Agonists in Combination with the Dopamine D2 Agonist Quinpirole Produce Locomotor Stimulation in Dopamine-Depleted Mice

Galia Eshel; Svante, B. Ross; Diana Kelder; Lil, E. M. Edis; David, M. Jackson

Basic and Clinical Pharmacology and Toxicology 67(2): 123-131

1990

ISSN/ISBN: 1742-7835
DOI: 10.1111/j.1600-0773.1990.tb00797.x
Accession: 062143815
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Mice were premedicated with reserpine and alpha-methyl-p-tyrosine to deplete stores of dopamine (DA) (and other neurotransmitters) and to stop DA (and noradrenaline (NA) synthesis. In DA-depleted mice, the mixed alpha 1/alpha 2 agonist clonidine potentiated locomotor stimulation induced by a low dose of apomorphine as measured in automated activity cages.

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Related References

Eshel, G.; Ross, S.B.; Kelder, D.; Edis, L.E.; Jackson, D.M. 1990: Alpha 1 (but not alpha 2)-adrenoceptor agonists in combination with the dopamine D2 agonist quinpirole produce locomotor stimulation in dopamine-depleted mice Pharmacology and Toxicology 67(2): 123-131
Eshel, G.; Edis, L.E.M.; Ross, S.B.; Kelder, D.; Jackson, D.M. 1990: Alpha 1 adrenoceptor agonists behave like dopamine d1 agonists in reinstating quiniprole locomotor stimulation blocked by dopamine depletion in mice European Journal of Pharmacology 183(2): 407
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