+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Epidemiology, associated burden, and current clinical practice for the diagnosis and management of Alzheimer's disease in Japan

Epidemiology, associated burden, and current clinical practice for the diagnosis and management of Alzheimer's disease in Japan

Clinicoeconomics and Outcomes Research 10: 13-28

The burden of dementia in Japan is large and growing. With the world's fastest aging population, it is estimated that one in five elderly people will be living with dementia in Japan by 2025. The most common form of dementia is Alzheimer's disease (AD), accounting for around two-thirds of dementia cases. A systematic review was conducted to examine the epidemiology and associated burden of AD in Japan and to identify how AD is diagnosed and managed in Japan. English and Japanese language databases were searched for articles published between January 2000 and November 2015. Relevant Japanese sources, clinical practice guideline registers, and reference lists were also searched. Systematic reviews and cohort and case-control studies were eligible for inclusion, with a total of 60 studies included. The most recent national survey conducted in six regions of Japan reported the mean prevalence of dementia in people aged ≥65 years to be 15.75% (95% CI: 12.4, 22.2%), which is much higher than the previous estimated rate of 10% in 2010. AD was confirmed as the predominant type of dementia, accounting for 65.8% of all cases. Advancing age and low education were the most consistently reported risk factors for AD dementia. Japanese guidelines for the management of dementia were released in 2010 providing specific guidance for AD about clinical signs, image findings, biochemical markers, and treatment approaches. Pharmacotherapies and non-pharmacotherapies to relieve cognitive symptoms were introduced, as were recommendations to achieve better patient care. No studies reporting treatment patterns were identified. Due to population aging and growing awareness of AD in Japan, health care expenditure and associated burden are expected to soar. This review highlights the importance of early detection, diagnosis, and treatment of AD as strategies to minimize the impact of AD on society in Japan.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 062175071

Download citation: RISBibTeXText

PMID: 29343976

DOI: 10.2147/CEOR.S146788

Related references

Unstable angina and non-ST elevation acute coronary syndrome: epidemiology and current management in Japan (Japan Multicenter Investigation for Cardiovascular Disease-D (JMIC-D) Committee). Circulation Journal 71(9): 1335-1347, 2007

Epidemiology and Clinical Diagnosis: Alzheimer Disease. Pet Clinics 8(4): 391-405, 2013

Alzheimer's disease: clinical update on epidemiology, pathophysiology and diagnosis. Australasian Psychiatry 26(4): 347-357, 2018

Current diagnostic tests for Alzheimer's disease in clinical practice. Nederlands Tijdschrift Voor Geneeskunde 140(42): 2071-2073, 1996

Epidemiology, diagnosis, and management of Alzheimer's disease and related disorders: implications for minority populations. Health Matrix 6(4): 28-32, 1988

Cerebrospinal fluid biomarkers of Alzheimer's disease in current clinical practice. Revue Medicale Suisse 12(515): 791-794, 2016

Pharmacological therapy in Alzheimer's disease. Current clinical practice in The Netherlands. Tijdschrift Voor Gerontologie en Geriatrie 36(3): 122-126, 2005

Alzheimer's disease diagnosis disclosure in Brazil: a survey of specialized physicians' current practice and attitudes. International Psychogeriatrics 20(3): 471-481, 2007

Clinical and economic burden in patients with diagnosis of peripheral arterial disease in a claims database in Japan. Clinical Therapeutics 36(8): 1223-30, 1230.E1-4, 2016

Use of CSF biomarkers in the diagnosis of Alzheimer's disease in clinical practice. Revue Neurologique 167(6-7): 474-484, 2011

Rivastigmine in current clinical practice in patients with mild to moderate Alzheimer's disease. Revue Neurologique 158(8-9): 807-812, 2002

The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease. Advances in Parasitology 96: 259-369, 2017

European survey on current practice and disclosure of the diagnosis of Alzheimer's disease. A study based on caregiver's report. Psychologie and Neuropsychiatrie du Vieillissement 1(1): 45-55, 2005

Neuroimaging in Alzheimer's disease: current role in clinical practice and potential future applications. Clinics 66 Suppl 1: 19-24, 2012

Circadian Rhythms Disturbances in Alzheimer Disease: Current Concepts, Diagnosis, and Management. Alzheimer Disease and Associated Disorders 32(2): 162-171, 2018