Structural determinants within residues 180-199 of the rodent .alpha.5 nicotinic acetylcholine receptor subunit involved in .alpha.-bungarotoxin binding
McLane, K E.; Wu, X; Conti-Tronconi, B M.
Biochemistry 30(44): 10730-10738
ISSN/ISBN: 0006-2960 DOI: 10.1021/bi00108a018
Synthetic peptides corresponding to sequence segments of the nicotinic acetylcholine receptor (nAChR) alpha subunits have been used to identify regions that contribute to formation of the binding sites for cholinergic ligands. We have previously defined alpha-bungarotoxin (alpha-BTX) binding sequences between residues 180 and 199 of a putative rat neuronal nAChR alpha subunit, designated alpha 5 (McLane, K. E., Wu, X., & Conti-Tronconi, B. M. (1990) J. Biol.