Application of arylsulphonyl side-chain protected arginines in solid-phase peptide synthesis based on 9- fluorenylmethoxycarbonyl amino protecting strategy
Peter, M. Fischer; Kim, V. Retson; Margaret, I. Tyler; Merlin, E.H. Howden
Chemical Biology and Drug Design 40(1): 19-24
ISSN/ISBN: 1747-0277 DOI: 10.1111/j.1399-3011.1992.tb00100.x
One of the main problems still hampering solid-phase peptide synthesis using orthogonal protection strategies based on the 9-fluorenylmethoxycarbonyl amino protecting group is the difficult removal of currently used arginine arylsulphonyl guanidino protecting groups. Poor acid lability of 4-methoxy-2,3,6-trimethylbenzenesulphonyl-protected arginine has led to the popularity of the newer 2,2,5,7,8-pentamethylchroman-6-sulphonyl guanidino protecting group.