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Application of arylsulphonyl side-chain protected arginines in solid-phase peptide synthesis based on 9- fluorenylmethoxycarbonyl amino protecting strategy

Peter, M. Fischer; Kim, V. Retson; Margaret, I. Tyler; Merlin, E.H. Howden

Chemical Biology and Drug Design 40(1): 19-24

1992

ISSN/ISBN: 1747-0277
DOI: 10.1111/j.1399-3011.1992.tb00100.x
Accession: 062217898
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One of the main problems still hampering solid-phase peptide synthesis using orthogonal protection strategies based on the 9-fluorenylmethoxycarbonyl amino protecting group is the difficult removal of currently used arginine arylsulphonyl guanidino protecting groups. Poor acid lability of 4-methoxy-2,3,6-trimethylbenzenesulphonyl-protected arginine has led to the popularity of the newer 2,2,5,7,8-pentamethylchroman-6-sulphonyl guanidino protecting group.

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Related References

Fischer, P.M.; Retson, K.V.; Tyler, M.I.; Howden, M.E. 1992: Application of arylsulphonyl side-chain protected arginines in solid-phase peptide synthesis based on 9-fluorenylmethoxycarbonyl amino protecting strategy International Journal of Peptide and Protein Research 40(1): 19-24
Fischer, P.M.; Zheleva, D.I. 2002: Liquid-phase peptide synthesis on polyethylene glycol (PEG) supports using strategies based on the 9-fluorenylmethoxycarbonyl amino protecting group: application of PEGylated peptides in biochemical assays Journal of Peptide Science: An Official Publication of the European Peptide Society 8(9): 529-542
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