Selective Regulation of Eosinophil Degranulation by Interleukin 1 

Baskar, P.; Pincus, S. H.

Experimental Biology and Medicine 199(2): 249-254


ISSN/ISBN: 1535-3702
DOI: 10.3181/00379727-199-43355
Accession: 062262627

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Recent evidence confirms that cytokines such as IL-1, IL-4, IL-5, and GM-Csf may enhance or inhibit eosinophil function. Functions that are susceptible to modulation include eosinophil-mediated antibody-dependent damage of helminthic parasites, oxidative metabolism and degranulation. We have employed Ig G and Ig E-coated Sepharose beads to investigate selective modulation of Ig G and Ig E-mediated enzyme release by IL-1β. Both Ig G and Ig E-coated beads induced release of granular enzymes β-glucuronidase and arylsulfatase. Enzyme release from Ig G-stimulated eosinophils was inhibited by preincubation with IL-1β (100 pg/ml, P ≤ 0.05). In contrast, enzyme release by Ig E-stimulated eosinophils was enhanced by IL-1β (100 pg/ml, P ≤ 0.05). These studies support the hypothesis that IL-1β has specific selective actions on eosinophil function. Furthermore, these actions on particle-stimulated enzyme release suggest that Ig G and Ig E mediated processes in eosinophils are differentially regulated.