Section 63
Chapter 62,306

Fate of 14C radiolabeled poly (dl-lactic acid) nanoparticles following oral administration to rats

Ropert, C.; Bazile, D.; Bredenbach, J.; Marlard, M.; Veillard, M.; Spenlehauer, G.

Colloids and Surfaces B Biointerfaces 1(4): 233-239


DOI: 10.1016/0927-7765(93)80023-r
Accession: 062305750

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Because of their size (< 250 nm), nanoparticles can be regarded as interesting devices to increase the oral bioavailability of drugs. We prepared 14C-poly (dl-lactic acid) nanoparticles by a microfluidization and solvent evaporation process using the albumin as surfactant. After oral administration the radiolabel crosses the intestinal barrier and 17.8% of the radioactivity is recovered in urinary and pulmonary excretions and in the blood.

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