Fate of 14C radiolabeled poly (dl-lactic acid) nanoparticles following oral administration to rats
Ropert, C.; Bazile, D.; Bredenbach, J.; Marlard, M.; Veillard, M.; Spenlehauer, G.
Colloids and Surfaces B Biointerfaces 1(4): 233-239
Because of their size (< 250 nm), nanoparticles can be regarded as interesting devices to increase the oral bioavailability of drugs. We prepared 14C-poly (dl-lactic acid) nanoparticles by a microfluidization and solvent evaporation process using the albumin as surfactant. After oral administration the radiolabel crosses the intestinal barrier and 17.8% of the radioactivity is recovered in urinary and pulmonary excretions and in the blood.