The application of canonical analysis to the evaluation of the influence of changes in components of standard direct compression tablet formulations
Fridrun Podczeck; Gabriele Merkel; Piroska Révész
International Journal of Pharmaceutics 97(1-3): 15-28
ISSN/ISBN: 0378-5173 DOI: 10.1016/0378-5173(93)90122-v
Different types of microcrystalline and microfine celluloses are often used in direct tabletting mixtures. An evaluation has been undertaken of the connection between the pharmaceutical behaviour of a range of the cellulose products and the powder and tablet properties of the tabletting mixtures, using the multivariate statistical technique of canonical analysis.