Localization of the human α-fodrin gene (SPTAN1) to 9q33→q34 by fluorescence in situ hybridization

Upender, M.; Gallagher, P.G.; Moon, R.T.; Ward, D.C.; Forget, B.G.

Cytogenetic and Genome Research 66(1): 39-41


ISSN/ISBN: 1424-8581
DOI: 10.1159/000133660
Accession: 062390414

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Using fluorescence in situ hybridization, the human alpha-fodrin gene (nonerythroid alpha spectrin, SPTAN1), a member of the spectrin gene superfamily, was mapped to 9q33-->q34. This locus is near the translocation breakpoint region in the Philadelphia (Ph1) chromosome, t(9;22)(q34;q11). In a human chronic myelogenous leukemia cell line with the Ph1 chromosome, K562, the alpha-fodrin gene mapped centromeric to the translocation breakpoint, indicating that the alpha-fodrin gene is not translocated to the Ph1 chromosome in this cell line.