Radiogenic transformation of human mammary epithelial cells in vitro
Chui, T.-Yang, H.; Kerry, G.A.; Tavakoli, A.; Laurie, C.M.; Durante, M.
Radiation Oncology Investigations 3(6): 412-419
ISSN/ISBN: 1065-7541 DOI: 10.1002/roi.2970030631
Cancer induction by space radiations is a major concern for manned space exploration. Accurate assessment of radiation risk at low doses requires basic understanding of mechanism(s) of radiation carcinogenesis. For determining the oncogenic effects of ionizing radiation in human epithelial cells, we transformed a mammary epithelial cell line (185B5), which was immortalized by benzo(a)pyrene, with energetic heavy ions and obtained several transformed clones.