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The 3-untranslated region of the mouse cholesterol 7a-hydroxylase mRNA contains elements responsive to post-transcriptional regulation by bile acids

AGELLON, B. Luis; CHEEMA, K. Sukhinder

Biochemical Journal 328(2): 393-399

1997

ISSN/ISBN: 0264-6021
DOI: 10.1042/bj3280393
Accession: 062657038
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To investigate the importance of the 3'-untranslated region (UTR) of the mouse cholesterol 7alpha-hydroxylase (cyp7) mRNA in post-transcriptional regulation of expression of the cyp7 gene, chimaeric genes encoding mRNA containing the structural sequence of chloramphenicol acetyltransferase (CAT) linked to either the 3'-UTR of the mouse cyp7 mRNA or the SV40 early gene mRNA were constructed. The human cytomegalovirus (CMV) promoter was used to drive the expression of all the chimaeric genes.

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Related References

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