+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Estimating causal log-odds ratio using the case-control sample and its application in the pharmaco-epidemiology study

Estimating causal log-odds ratio using the case-control sample and its application in the pharmaco-epidemiology study

Statistical Methods in Medical Research 28(7): 2165-2178

ISSN/ISBN: 0962-2802

PMID: 29355073

DOI: 10.1177/0962280217750175

One important goal in pharmaco-epidemiology studies is to understand the causal relationship between drug exposures and their clinical outcomes, including adverse drug events. In order to achieve this goal, however, we need to resolve several challenges. Most of pharmaco-epidemiology data are observational and confounding is largely present due to many co-medications. The pharmaco-epidemiology study data set is often sampled from large medical record databases using a matched case-control design, and it may not be representative of the original patient population in the medical record databases. Data analysis method needs to handle a large sample size that cannot be handled using existing statistical analysis packages. In this paper, we tackle these challenges both methodologically and computationally. We propose a conditional causal log-odds ratio (OR) definition to characterize causal effects of drug exposures on a binary adverse drug event adjusting for individual level confounders. Using a case-control design, we present a propensity score estimation using only case samples and we provide sufficient conditions for the consistency of the estimation of the causal log-odds ratio using case-based propensity scores. Computationally, we implement a principle component analysis to reduce high-dimensional confounders. Extensive simulation studies are performed to demonstrate superior performance of our method to existing methods. Finally, we apply the proposed method to analyze drug-induced myopathy data sampled from a de-identified subset of medical record database (close to 5 million patient records), The Indiana Network for Patient Care. Our method identified 70 drug-induced myopathy (p < 0.05) out 72 drugs, which have myoathy side effects on their FDA drug labels. These 70 drugs include three statins who are known for their myopathy side effects.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 062657067

Download citation: RISBibTeXText

Related references

Estimating a marginal causal odds ratio in a case-control design: analyzing the effect of low birth weight on the risk of type 1 diabetes mellitus. Statistics in Medicine 32(14): 2500-2512, 2013

Estimating a Marginal Causal Odds Ratio Subject to Confounding. Communications in Statistics. Theory and Methods 38(3-5): 309-321, 2009

Sample sizes for estimation of the odds ratio in unmatched case-control studies. American Journal of Epidemiology 120(1): 145-153, 1984

Two-stage instrumental variable methods for estimating the causal odds ratio: analysis of bias. Statistics in Medicine 30(15): 1809-1824, 2011

Small-sample properties of odds ratio estimators under multiple matching in case-control studies. Biometrics 46: 9, 1990

A simple method for estimating the odds ratio in matched case-control studies with incomplete paired data. Statistics in Medicine 31(27): 3299-3312, 2012

Sample size determination for pair-matched case-control studies where the goal is interval estimation of the odds ratio. Journal of Clinical Epidemiology 43(1): 55-59, 1990

The case-only odds ratio as a causal parameter. Biometrics 60(1): 233-240, 2004

Application of odds ratio regression models for assessing familial aggregation from case-control studies. American Journal of Epidemiology 124(4): 678-683, 1986

Unbiased confidence intervals for the odds ratio of two independent binomial samples with application to case-control data. Biometrics 57(2): 484-489, 2001

Performance of the Peto odds ratio compared to the usual odds ratio estimator in the case of rare events. Biometrical Journal. Biometrische Zeitschrift 58(6): 1428-1444, 2016

Evaluation of the propensity score methods for estimating marginal odds ratios in case of small sample size. Bmc Medical Research Methodology 12: 70, 2012

Sample size considerations in active-control non-inferiority trials with binary data based on the odds ratio. Statistical Methods in Medical Research 24(4): 453-461, 2015

Semiparametric odds ratio model for case-control and matched case-control designs. Statistics in Medicine 32(18): 3126-3142, 2013

Inverse probability weighted estimation of the marginal odds ratio: correspondence regarding 'The performance of different propensity score methods for estimating marginal odds ratios'. Statistics in medicine 27(26): 5556-9; author reply 5560-3, 2008