Section 63
Chapter 62,928

Shedding of interleukin-6 receptor and tumor necrosis factor α : Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins

Katja Althoff; Pranitha Reddy; Nicole Voltz; Stefan Rose-John; Jürgen Müllberg

Febs Journal 267(9): 2624-2631


ISSN/ISBN: 1742-464X
DOI: 10.1046/j.1432-1327.2000.01278.x
Accession: 062927361

Download citation:  

A functionally and structurally diverse group of transmembrane proteins including transmembrane forms of mediators or receptors can be proteolytically cleaved to form soluble growth factors or receptors. Recently, the proteolytic activity responsible for pro-tumor necrosis factor alpha (proTNFalpha) processing has been identified and named TACE (TNFalpha converting enzyme).

PDF emailed within 0-6 h: $19.90