Behandlung von Pruritus als Symptom von Hauterkrankungen mit dem Serotonin-Rezeptorantagonisten Ondansetron : Therapy of pruritus associated with skin diseases with the serotonin receptor antagonist ondansetron
Sabine Zenker; Theda Schuh; Klaus Degitz
Jddg Journal der Deutschen Dermatologischen Gesellschaft 1(9): 705-710
Pruritus is often a stressing symptom and a therapeutic challenge. We report our experience with the serotonin receptor antagonist ondansetron in the symptomatic treatment of pruritus accompanying various skin diseases. The influence of ondansetron (8-12 mg orally per day) on pruritus was assessed in twelve patients with various skin disorders. The intensity of pruritus was quantitated daily by a visual analogue scale over the time period of one week before, during, and one week after treatment. Ondansetron decreased pruritus intensity in prurigo simplex (four patients), asteatotic eczema (two patients), parapsoriasis en plaques, and pruritus of unknown origin (one patient each).