Direct regioselective benzoylation of a single C-2 hydroxyl group ofβ-cyclodextrin and its hydrolysis via benzoyl group migration
Zhi-zhong Wang; Meng-ying Liu; Run-hua Lu; Xue-yan Fu; Gui-dong Dai
Monatshefte fur Chemie 142(12): 1283-1287
2011
ISSN/ISBN: 0026-9247
DOI: 10.1007/s00706-011-0566-7
Accession: 064050572
A simple and efficient method for the direct regioselective benzoylation of a single C-2 hydroxyl group of beta-cyclodextrin was developed by using a combination of N,N'-carbonyldiimidazole and carbonate buffer in 1,4-dioxane, which does not require highly reactive reagents such as acyl chloride, or toxic solvents such as acetonitrile.