+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis



Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis



Oral Diseases 24(7): 1209-1216



Cancer stem cell (CSC) proteins have been observed in several lesions and are associated with tumor beginning, evolution, and resistance to treatment. To investigate the presence of NANOG, NESTIN, and β-tubulin in lip squamous cell carcinoma (LSCC), actinic cheilitis (AC), and normal epithelium (NE). Thirty cases of LSCC, thirty cases of AC (both analyzed according to the WHO classification and AC according to the binary classification), and twenty cases of NE were submitted to an immunohistochemical study. NANOG was more expressed in the nuclei of AC compared to NE (p = 0.007), as well as in high-risk AC cases (p = 0.017) and well-differentiated LSCCs (no significance). There was an accumulation of nuclear NANOG from mild to moderate and severe ACs. NESTIN was significantly less present in NE compared to AC (p = 0.001) and LSCC (p = 0.003). There was a higher expression in severe dysplasia or high-risk AC and well-differentiated LSCC. These results indicate an upregulation of NANOG and NESTIN in the early stages of carcinogenesis. β-tubulin was intensely present in all lesions. The results suggest an upregulation of NANOG and NESTIN in the biological behavior these diseases, mainly in the transformation from AC to LSCC.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 064315285

Download citation: RISBibTeXText

PMID: 29761881

DOI: 10.1111/odi.12891


Related references

Prognostic significance of neural stem cell markers, Nestin and Musashi-1, in oral squamous cell carcinoma: expression pattern of Nestin in the precancerous stages of oral squamous epithelium. Clinical Oral Investigations 19(6): 1251-1260, 2014

Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their relation to survivin expression. Pathology, Research and Practice 210(11): 751-758, 2014

Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 112(3): 342-348, 2012

A retrospective review of the prognostic value of ALDH-1, Bmi-1 and Nanog stem cell markers in esophageal squamous cell carcinoma. Plos One 9(8): E105676-E105676, 2015

Altered β-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip. Annals of Diagnostic Pathology 15(1): 1-5, 2011

Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma. Cancer Immunology, ImmunoTherapy 60(7): 965-974, 2011

Association of mast cell, eosinophil leucocyte and microvessel densities in actinic cheilitis and lip squamous cell carcinoma. Histopathology 57(6): 796-805, 2011

Comparative analysis of the mast cell density in normal oral mucosa, actinic cheilitis and lip squamous cell carcinoma. Brazilian Dental Journal 19(3): 186-189, 2008

Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. European Archives of Oto-Rhino-Laryngology, 2018

Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. Molecular and Clinical Oncology 8(5): 640-646, 2018

A case of metastatic squamous cell carcinoma arising from actinic cheilitis. Annals of Dermatology 23(1): 101-103, 2011

Characterization of OCT3/4, Nestin, NANOG, CD44 and CD24 as stem cell markers in canine prostate cancer. International Journal of Biochemistry & Cell Biology 2019, 2019

Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects. Anais Brasileiros de Dermatologia 87(1): 105-114, 2012

Density and migration of mast cells in lip squamous cell carcinoma and actinic cheilitis. Histology and Histopathology 24(4): 457-465, 2009

Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil. Journal of Clinical and Experimental Dentistry 11(1): E62-E69, 2019