Synthesis, biological screening and ADME prediction of benzylindole derivatives as novel anti-HIV-1, anti-fungal and anti-bacterial agents

Kashid, A.M.D.P.N.A.P.G.B.K.G.…

Medicinal Chemistry Research 22(10): 4633-4640


ISSN/ISBN: 1054-2523
DOI: 10.1007/s00044-012-0463-6
Accession: 064395670

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Present study is focused on design, synthesis, and biological evaluation of substituted benzylindole derivatives as anti-HIV, anti-fungal, and anti-bacterial agents. Out of the reported compounds, compound B1 and B2 showed potent Anti-Hiv activity, whereas compound B1–B4 showed good anti-fungal and anti-bacterial activity. Adme properties of benzylindol analogs were analyzed using Qikprop 2.5 tool of Schrodinger.