Hybrid probes of aromatic amine and barbituric acid: highly promising leads for anti-bacterial, anti-fungal and anti-cancer activities
Dhorajiya, B D.; Dholakiya, B Z.; Mohareb, R M.
Medicinal Chemistry Research 23(9): 3941-3952
ISSN/ISBN: 1054-2523 DOI: 10.1007/s00044-014-0973-5
Today, cancer and resistant microbes remain one of the most deadly diseases in the world. In search of novel anti-cancer and anti-microbial probes, a series of newly hybrid molecules is synthesized by combining the structural features of aromatic amines and barbituric acid, using the concept of green chemistry. This approach was accomplished efficiently using water as the greener solvent and in the absence of catalyst to give the corresponding adducts. All newly synthesized compounds were characterized by spectral analysis FT-IR, 1H NMR, 13C NMR, Hmbc and Elemental Analysis.