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Apoptotic Endonuclease EndoG Induces Alternative Splicing of Telomerase TERT Catalytic Subunit, Caspase-2, DNase I, and BCL-x in Human, Murine, and Rat CD4+ T Lymphocytes

Zhdanov, D. D.; Gladilina, Y. A.; Grishin, D. V.; Pokrovsky, V. S.; Pokrovskaya, M. V.; Aleksandrova, S. S.; Sokolov, N. N.

Russian Journal of Bioorganic Chemistry 44(1): 90-103

2018

ISSN/ISBN: 1068-1620
DOI: 10.1134/s1068162018010181
Accession: 065082908
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Apoptotic endonuclease Endo G plays a key role in the alternative splicing of m Rna of human Tert telomerase catalytic subunit. The aim of this work was to test the ability of Endo G to induce alternative splicing of m Rna of other genes and in other organisms. To determine new m Rna splice-variants, Endo G overexpression was induced in human, mouse and rat CD4+-T-lymphocytes followed by sequencing of total Rna of these cells.

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Sikora, E.; Bielak-Zmijewska, A.; Magalska, A.; Piwocka, K.; Mosieniak, G.; Kalinowska, M.; Widlak, P.; Cymerman, I.A.; Bujnicki, J.M. 2006: Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells Molecular Cancer Therapeutics 5(4): 927-934
Brenner, C.A.; Wolny, Y.M.; Adler, R.R.; Cohen, J. 1999: Alternative splicing of the telomerase catalytic subunit in human oocytes and embryos Molecular Human Reproduction 5(9): 845-850
Partheniou, F.; Jiang, X.R.; Kelsey, S.M.; Newland, A.C. 1999: Differentiation induces upregulation of telomerase-associated protein 1 as opposed to the downregulation of human telomerase catalytic subunit gene and telomerase activity in human leukaemic cells British Journal of Haematology 105(Suppl 1): 94
Yi, X.; White, D.M.; Aisner, D.L.; Baur, J.A.; Wright, W.E.; Shay, J.W. 2000: An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity Neoplasia 2(5): 433-440
Soares, J.; Lowe, M.M.; Jarstfer, M.B. 2011: The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate Biochemistry 50(42): 9046-9055
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Hu, B.T.; Insel, R.A. 1999: Up-regulation of telomerase in human B lymphocytes occurs independently of cellular proliferation and with expression of the telomerase catalytic subunit European Journal of Immunology 29(11): 3745-3753
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