Apoptotic Endonuclease EndoG Induces Alternative Splicing of Telomerase TERT Catalytic Subunit, Caspase-2, DNase I, and BCL-x in Human, Murine, and Rat CD4+ T Lymphocytes
Zhdanov, D. D.; Gladilina, Y. A.; Grishin, D. V.; Pokrovsky, V. S.; Pokrovskaya, M. V.; Aleksandrova, S. S.; Sokolov, N. N.
Russian Journal of Bioorganic Chemistry 44(1): 90-103
ISSN/ISBN: 1068-1620 DOI: 10.1134/s1068162018010181
Apoptotic endonuclease Endo G plays a key role in the alternative splicing of m Rna of human Tert telomerase catalytic subunit. The aim of this work was to test the ability of Endo G to induce alternative splicing of m Rna of other genes and in other organisms. To determine new m Rna splice-variants, Endo G overexpression was induced in human, mouse and rat CD4+-T-lymphocytes followed by sequencing of total Rna of these cells.