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Hepatic fibropoiesis in dogs naturally infected with Leishmania (Leishmania) infantum treated with liposome-encapsulated meglumine antimoniate and allopurinol

Castro, R.S.; de Amorim, I.F.G.; Pereira, R.A.; Silva, S.M.; Pinheiro, L.J.; Pinto, A.J.W.; Azevedo, E.G.; Demicheli, C.; Caliari, M.M.V.; Mosser, D.M.; Michalick, M.S.M.; Frezard, Fédéric J.G.; Tafuri, W L.

Veterinary Parasitology 250: 22-29

2018


ISSN/ISBN: 0304-4017
DOI: 10.1016/j.vetpar.2017.12.005
Accession: 065106573

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Hepatic fibropoiesis in canine visceral leishmaniasis (CVL) were evaluated by histological (morphometrical collagen deposition) and immunohistochemical assays characterizing alpha-actin (α-SMA), vimentin, calprotectin (L1 antigen), and TGF-β in 46 naturally infected dogs with Leishmania infantum treated with liposome-encapsulated meglumine antimoniate and allopurinol separately and in combination.

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