+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Foot and ankle characteristics in systemic lupus erythematosus: A systematic review and meta-analysis



Foot and ankle characteristics in systemic lupus erythematosus: A systematic review and meta-analysis



Seminars in Arthritis and Rheumatism 2018



To determine characteristics of the foot and ankle in people with systemic lupus erythematosus (SLE). Medline, CINAHL, Sports-Discus, Scopus and Cochrane Library databases were searched up to January 2018. Studies reporting foot- and ankle-related outcomes in the following domains were included: vascular, neurological, musculoskeletal, cutaneous (skin and nail) or pain/function. The Quality Index tool was used to assess methodological quality. Where appropriate, odds ratio (OR) and mean difference meta-analyses were conducted for case-control studies; and pooled mean prevalence meta-analyses for studies assessing characteristics in SLE. Forty-nine studies were included with mean (range) quality scores of 75% (38-100%). Twenty-three studies assessed vascular characteristics, followed by musculoskeletal (n = 16), neurological (n = 11), cutaneous (n = 5) and pain/function (n = 4). Foot and ankle characteristics in people with SLE included impaired vascular supply, abnormal nerve function, musculoskeletal pathology, skin and nail pathology, and pain and functional disability. Twenty-four studies were included in meta-analyses. Pooled OR for abnormal ankle brachial index was 3.08 for SLE compared with controls. Pooled mean difference in brachial-ankle pulse-wave velocity between SLE and controls was significant (161.39 cm/s, P = 0.004). Pooled prevalence was 0.54 for intermittent claudication, 0.50 for Raynaud's phenomenon, 0.28 for chilblains, 0.00 for gangrene, 0.30 for hallux valgus, 0.15 for onychomycosis, 0.76 for history of foot pain, and 0.36 for current foot pain. People with SLE experience a wide range of foot and ankle manifestations. Published research highlights the impact of peripheral arterial disease, peripheral neuropathy, musculoskeletal deformity, skin and nail pathology and patient-reported foot pain and disability.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065158177

Download citation: RISBibTeXText

PMID: 30093237

DOI: 10.1016/j.semarthrit.2018.07.002


Related references

A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis. Clinical Journal of the American Society of Nephrology 5(11): 2060-2068, 2011

Rituximab in systemic lupus erythematosus: an updated systematic review and meta-analysis. Lupus 22(14): 1489-1503, 2014

Association between Systemic Lupus Erythematosus and Periodontitis: A Systematic Review and Meta-analysis. Frontiers in Immunology 8: 1295, 2017

Associations between TLR polymorphisms and systemic lupus erythematosus: a systematic review and meta-analysis. Clinical and Experimental Rheumatology 30(2): 262-265, 2012

Prevalence of depression and anxiety in systemic lupus erythematosus: a systematic review and meta-analysis. Bmc Psychiatry 17(1): 70, 2017

Thrombocytopenia as a Prognostic Marker for Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis. American Journal of the Medical Sciences 2019, 2019

Assessment of subclinical atherosclerosis in systemic lupus erythematosus: A systematic review and meta-analysis. Joint, Bone, Spine 85(2): 155-163, 2017

SAT0446The prevalence of systemic lupus erythematosus in europe: A systematic review and meta-analysis. Annals of the Rheumatic Diseases 71(Suppl 3): 623.1-623, 2013

SAT0389Assessment of Subclinical Atherosclerosis in Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis. Annals of the Rheumatic Diseases 74(Suppl 2): 800.2-800, 2015

Gait characteristics associated with the foot and ankle in inflammatory arthritis: a systematic review and meta-analysis. Bmc Musculoskeletal Disorders 16: 134, 2015

Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis. Clinical Rheumatology 27(12): 1557-1563, 2008

Predictors of cardiovascular events in patients with systemic lupus erythematosus (SLE): a systematic review and meta-analysis. European Journal of Preventive Cardiology 22(11): 1435-1441, 2016

Prevalence of cervical HPV infection in women with systemic lupus erythematosus: A systematic review and meta-analysis. Autoimmunity Reviews 2018, 2018

Association of the CTLA-4 1722TC polymorphism and systemic lupus erythematosus: a systematic review and meta analysis. Medical Journal of the Islamic Republic of Iran 28: 132, 2015

The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis. Arthritis Research and Therapy 20(1): 270, 2018